Cardiovascular Function and Risk Factors

Enhanced stroke volume and divergence of the human left ventricle

The paper compares left ventricular phenotypes across humans, chimpanzees, and macaques to identify structural and functional traits associated with higher stroke volume in humans.

Joint Vector Flow Mapping and Segmentation: Ill-Posedness,Differentiable Bayesian Inference, and Synthetic Vortex-FlowBenchmarks

This paper introduces Bayesian VFM (B-VFM) to address ill-posedness in vector flow mapping by jointly inferring velocity fields, segmentation masks, and uncertainties using Bayesian inference.

Inotropic effects of 3-hydroxybutyrate in a rodent heart: pressure-volume and isolated rat ventricular trabeculae analysis

This study investigates the inotropic effects of 3-hydroxybutyrate in rat hearts using pressure-volume analysis and isolated ventricular trabeculae, finding direct myocardial improvement independent of beta-adrenergic signaling.

Nitric oxide synthase inhibition and biological sex define different cardiac responses to cardiometabolic stress in older mice.

This study shows that biological sex and nitric oxide synthase inhibition lead to different cardiac responses to cardiometabolic stress in older mice, resulting in distinct HFpEF-like or HFrEF-like phenotypes.

Normalizing LZ+ MYPT1 Expression Prevents the Development of HFpEF

This study shows that maintaining normal LZ+ MYPT1 expression prevents HFpEF development in mice by improving vascular reactivity and diastolic function.

Shared and Divergent Features of Cardiac Transcriptome and Glucose Metabolism Markers in Human and Mouse HFpEF

This study compares cardiac transcriptome and glucose metabolism markers in human and mouse HFpEF, finding greater conservation in right ventricles and sex-specific differences in left ventricles.

Analytical resolution governs cross-laboratory and cross-species concordance in murine cardiometabolic HFpEF transcriptomics

This paper assesses reproducibility of murine HFpEF transcriptomics across labs and species, finding that pathway-level agreement is high but gene-level agreement varies widely.

A Theoretical Framework for the Hemodynamic Role of Sarcomere Length Dynamics During the Isovolumic Phases of the Left Ventricle

This study develops a theoretical framework to analyze how sarcomere length dynamics during the isovolumic phase affect contraction and relaxation time in the left ventricle.

Cardiomyocyte pyruvate dehydrogenase kinase 1 knockout activates Rho-mediated remodeling and decreases fatty acyl availability in female mice

This study shows that PDK1 knockout in female mice leads to cardiac metabolic remodeling and reduced fatty acyl availability, while male mice show no such effects.

A Translational Model of MASLD-Associated HFpEF Defines Mitochondrial Dysfunction and Cardiac Plasticity During Disease Progression and Regression

This paper develops a mouse model of MASLD-associated HFpEF, showing mitochondrial dysfunction and cardiac plasticity, and demonstrates reversibility with dietary intervention.

Estrogen-Deficiency Degrades Left Ventricular Diastolic Function and Energy Metabolism in Hypertensive Female Mice

This study shows that estrogen deficiency worsens diastolic dysfunction and energy metabolism in hypertensive female mice, with improvements seen when estrogen or its receptor agonists are administered.

Hepatic Acetate is an Essential Fuel for the Heart during Energy-Deprived States

This study identifies acetate as a critical metabolic fuel for the heart during fasting, showing its uptake and utilization via Acss1-dependent pathway.

Ultrasound-Based Hemodynamic Force Trajectories in a Murine Model of Reversible Pressure Overload

This study uses high-resolution echocardiography in mice to track hemodynamic force metrics during pressure overload and recovery, finding systolic HDF ratios strongly correlate with cardiac dysfunction and recovery.

Remodeling-mediated changes in left ventricular mechanics under settings of chronic pressure overload and exercise

This study uses speckle-tracking echocardiography to monitor LV remodeling in porcine models of pressure overload, exercise, and their combination, finding divergent effects on myocardial and chamber stiffness.

Empagliflozin preserves cardiac function and modulates metabolism in a mouse model of Duchenne muscular dystrophy

This study shows empagliflozin improves cardiac function and mitochondrial health in a mouse model of Duchenne muscular dystrophy.

EchoVisuALL: From Echocardiography to Gene Discovery

EchoVisuALL automates echocardiography analysis in mice, identifying 37 genes linked to cardiac abnormalities through phenotyping and clustering.

Does PERM1 Regulate Systolic Cardiac Function? A Game of Numbers.

This study investigates whether PERM1 regulates systolic cardiac function by conducting a large-scale echocardiography analysis with increased sample size, finding significant differences in cardiac parameters between Perm1-KO and WT mice.

Hepatic Ketogenesis Attenuates Cardiac Hypertrophy via Metabolic Reprogramming

This study shows that hepatic ketogenesis reduces cardiac hypertrophy in HFpEF by maintaining beta-hydroxybutyrate levels, which modulate myocardial metabolism.

Butyrate Rescues Cardiac Metabolic Dysfunction in Hypertensive Heart Failure with Preserved Ejection Fraction

This study shows that butyrate improves diastolic function and reduces fibrosis in hypertensive HFpEF rats by serving as an alternative energy source.

Targeting Metabolic Dysfunction and Inflammation with Sotagliflozin Reverses Diastolic Dysfunction in Experimental HFpEF

This study shows that sotagliflozin improves diastolic dysfunction in HFpEF by enhancing lipid metabolism and reducing inflammation.

Mechanistic Links Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Heart Failure with Preserved Ejection Fraction in a Mouse Model

This study investigates how MASLD worsens HFpEF in mice by identifying inflammatory and metabolic pathways linking liver steatosis to diastolic dysfunction.

Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse model

This paper develops a mouse model of diabetes-induced heart failure with preserved ejection fraction (HFpEF) by combining high-fat, high-sucrose diet and streptozotocin, showing distinct metabolic and cardiac changes compared to other HFpEF models.

The influence of captivity on cardiac structure and function across age, in rhesus macaques

This study compares cardiac structure and function in free-ranging and captive rhesus macaques across age, finding that captive macaques show more pronounced age-related cardiac changes.

Systemic Metabolic Rewiring in a Mouse Model of Left Ventricular Hypertrophy

This study investigates systemic metabolic changes in a mouse model of left ventricular hypertrophy, finding that exogenous long-chain fatty acid supplementation improves mitochondrial function but does not fully reverse the disease phenotype.

CAMK2-NR4A1 signaling initiates metabolic substrate switching to induce heart failure with reduced ejection fraction

The paper identifies CAMK2-NR4A1 signaling as a driver of metabolic substrate switching in heart failure with reduced ejection fraction, linking it to cardiac dysfunction through glucose utilization and lipid depletion.

Noncoding and Coding Mechanisms of Aging Heart Failure with Preserved Ejection Fraction with Thyroid Dysfunction

This study investigates the role of lncRNAs and thyroid dysfunction in aging HFpEF, identifying novel lncRNA and inflammatory markers in early and late stages.

Slow Calcium Removal Prolongs Ventricular Relaxation in Mice with HFpEF

This study identifies altered intracellular calcium handling in HFpEF mice, showing elevated diastolic calcium and slowed clearance as key contributors to impaired relaxation and exercise tolerance.

Multi-omics reveals lipid metabolism, mitochondrial and extracellular matrix dysregulation of diabetic cardiomyopathy in the human heart

This study uses multi-omics data to identify metabolic, mitochondrial, and extracellular matrix dysregulation in diabetic cardiomyopathy.

Metabolite-sensitive cross-bridge models of human atria reveal the impact of diabetes on muscle mechanoenergetics

This study uses metabolite-sensitive cross-bridge models of human atria to show diabetes impairs muscle mechanoenergetics by reducing cross-bridge stiffness and altering energy dynamics.

Flow transport and not ejection fraction determines left ventricular stasis in patients with impaired systolic function

The paper develops queue models to assess left ventricular blood transit and shows that flow transport, not ejection fraction, determines stasis in patients with impaired systolic function.