Temporomandibular Joint Disorders

This study develops a multiscale computational model linking TMJ structural changes to nociceptive activation by integrating biomechanics, neural morphology, and electrophysiology.

This study examines sensory and sympathetic nerve profiles in retrodiscal tissues of TMJD patients, finding reduced sensory nerve density in condylar hyperplasia compared to other subtypes.

This study evaluates how different levels of detail in finite element models affect stress-strain predictions in TMJ implants, finding that simplified models can be used for preliminary design but detailed models are needed for final evaluation.

This study models referred pain in mice by stimulating masticatory muscles and finds that TM stimulation induces longer-lasting headache-like behavior and gene plasticity in referred sites.

This study identifies FSP1-expressing cells as essential stem/progenitor cells in the TMJ condyle, showing their role in growth, homeostasis, and cartilage maintenance through Wnt signaling regulation.

This study uses in vivo GCaMP3 Ca2+ imaging to analyze neuronal activity in trigeminal ganglia of TMJ injury models, finding increased responsiveness to stimuli and the effectiveness of CGRP antagonists in reducing hypersensitivity.

This study investigates how forced mouth opening induces hyperalgesia and peripheral sensitization in mice following temporomandibular joint injury.

This study investigates how inflammation and tissue damage in masseter muscle relate to the resolution of chronic myalgia using CFA and collagenase-induced models.

This study evaluates the adaptive capacity of rabbit temporomandibular joints to unilateral changes in mandibular force vector direction, showing significant histomorphometric differences between test and control groups.