Blood Coagulation and Thrombosis Mechanisms

The paper introduces a novel rationale for targeting factor XI using miRNA mimics to develop anticoagulants that avoid disrupting hemostasis.

This study shows that disrupting the kringle 1 domain of prothrombin in zebrafish causes late-onset mortality due to impaired clot formation, revealing its role in thrombin biosynthesis and activation.

This study identifies transferrin as a clotting factor that modulates coagulation balance by interacting with clotting factors and antithrombin III, with implications for atherosclerosis.

The paper studies zebrafish factor V mutants to determine minimal hemostasis requirements and evaluates human F5 variants for their residual function.

This study shows thrombin cleaves PAR2 in a TM-dependent manner, leading to NF-κB activation and interleukin-8 release, suggesting a pro-inflammatory role for TM.

The paper identifies a de novo mutation in Plcb4 that suppresses thrombosis in mice with Factor V Leiden and tissue factor pathway inhibitor mutations.

The paper identifies novel thrombosis suppressor loci using a sensitized mutagenesis screen in Factor V Leiden mice, finding F8 and the Tfpi/F3 axis, as well as Actr2, play key roles in thrombosis regulation.