Trypanosoma species research and implications

The paper performs a genome-wide RNAi screen in Trypanosoma brucei to identify cell cycle regulators, identifying hundreds of proteins involved in different stages of the cell cycle and providing functional genomic insights.

The paper identifies a novel RNA-binding protein complex in Trypanosoma brucei and shows its role in mRNA translation and quality control.

The paper uses deep sequencing of mini-exon gene amplicons to analyze genetic diversity and mixed infections of Trypanosoma cruzi and T. rangeli in southern Ecuador, revealing underestimated T. rangeli prevalence and new TcIV sequences.

This study shows that PUF3 is not essential for Trypanosoma brucei growth or differentiation in vitro but may have a role in the invertebrate host or gene expression regulation.

This paper introduces a cost-effective method for analyzing pathogen genetic variation directly from host/vector material, demonstrating its ability to distinguish parasite strains and correlate genetic with geographic distances.

This study identifies small molecules that inhibit trypanosome growth and induce surface remodeling by promoting differentiation into insect-stage parasites.

The paper identifies PBP1-associated proteins in Trypanosoma brucei, showing their roles in mRNA stabilization and translation initiation complex recruitment.

This paper identifies ERBP1 and ERBP2 as ER-associated mRNA-binding proteins in T. brucei that interact and bind ribosomal protein mRNAs, but not secreted protein mRNAs or stress granules.

This study investigates mitochondrial gene expression changes in Trypanosoma cruzi during starvation, linking them to life stage transitions and morphological changes.

The paper develops a stochastic compartmental model to locate infested homes for Chagas disease vectors in urban areas using Bayesian methods and field testing.

The paper shows that transcription activity triggers non-constitutive origins in Trypanosoma brucei to ensure timely DNA replication.

The paper uses a T. brucei ORFeome to create a Gain-of-Function library and identifies novel genes linked to melarsoprol resistance.

This study identifies ZC3H20 and ZC3H21 as mRNA stabilizing factors in Trypanosoma brucei, showing they regulate membrane and mitochondrial protein mRNAs during developmental transitions.

This study shows that cAMP modulates oxidative stress resistance and infectivity differently in epimastigotes and trypomastigotes of Trypanosoma cruzi.

VAPPER enables high-throughput analysis of variant antigen repertoires in African trypanosomes, providing profiles and comparisons with existing strains.

This paper identifies functional protein features in REH2 and H2F1 that are critical for the assembly and stability of the REH2C complex in Trypanosoma brucei RNA editing.

This study uses long-read sequencing to analyze VSG diversity in T. brucei infections, revealing higher expressed diversity and early mosaic gene formation than previously observed.

The paper presents a comparative genomic analysis of six Glossina species, identifying genetic features related to their unique biology and vectorial capacity.

The paper analyzes genetic structure and sodium channel gene mutations in Triatoma infestans populations to understand pyrethroid insecticide resistance and gene flow patterns in Bolivia.

The paper designs synthetic trypanolytic factors (synTLF) inspired by natural TLF complexes, demonstrating their ability to kill African trypanosomes through lysosomal lysis.

This study uses Nanopore sequencing to improve genome assembly of Trypanosoma cruzi, increasing contiguity and assembly size by ~16 Mb.

The paper uses nascent DNA proteomics to identify proteins involved in DNA replication fork dynamics in Trypanosoma brucei, revealing essential and unknown replication factors.

The paper maps R-loop activities across the genome of Trypanosoma brucei, revealing conserved and novel roles in transcription and genome dynamics.

This study shows that ATR kinase in Trypanosoma brucei is essential for DNA damage signaling and controls monoallelic VSG expression during antigenic variation.

This study shows that 4EIP suppresses mRNA translation in Trypanosoma brucei and is required for differentiation to stumpy forms.

The paper investigates RNA-chaperone activity of OB-fold proteins in the Trypanosoma brucei editosome, showing activity differences correlate with surface areas and intrinsically disordered subdomains.

The paper explains a VSG hierarchy in Trypanosoma brucei infections through a growth-rate mechanism linked to VSG length, showing shorter VSGs trigger immune responses while longer VSGs persist due to slower growth.

The paper identifies a post-transcriptional regulatory element in the 3UTR of a lifecycle stage-regulated gene in Trypanosoma brucei that mediates glucose-responsive translational control.

The paper uses long-read sequencing to improve genome assembly and annotation of Trypanosoma cruzi, revealing new repetitive sequences and gene structures.

The paper investigates associations between APOL1 variants and HAT risk in Ugandan populations, finding no significant associations after correction for multiple testing.