Trypanosoma species research and implications

This study uses super-resolution microscopy to show that mucins and trans-sialidases in Trypanosoma cruzi are organized into distinct nanoscale domains with different structural and spatial arrangements.

This study shows that reducing IP6K levels in T. cruzi impairs key life-cycle transitions and intracellular development in human cardiomyocytes, suggesting IP6K as a potential drug target for Chagas disease.

This study investigates the role of CCDC40 in trypanosome flagellum structure and function, revealing that its depletion causes structural defects but not impaired cell division.

This study shows that during stage II of HAT infection, the brain reprograms its metabolism to use fatty acids and lipids instead of glucose, maintaining cognitive functions despite metabolic changes.

This study examines nonlinear dynamics of left ventricular mass remodeling in Chagas cardiomyopathy and links them to all-cause mortality using mathematical modeling and clinical data.

The paper characterizes the transcriptomes of two Rhodnius prolixus embryo-derived cell lines, identifying shared and distinct gene expression patterns that suggest different cell phenotypes.

This study identifies and characterizes TbPat, a triacylglycerol lipase in Trypanosoma brucei, showing its role in lipid mobilization and differentiation.

This study identifies RDK1's compartment-specific kinase activity and its role in maintaining the mitochondrial proteome in Trypanosoma brucei through proteomics and phosphoproteomics analyses.

This study determines the dimeric coiled-coil structure of the FAZ10 central region in Trypanosoma brucei using structural modeling and biophysical analysis.

This paper identifies the trypanosomatid dynamin-like protein (DLP) as associating with glycosomes and shows its role in glycosome maintenance through knockdown and overexpression experiments.

This study compares lipidomic profiles of Trypanosoma congolense and Trypanosoma brucei to understand their metabolic differences and implications for in vitro culture and therapy development.

The paper identifies the structure and stoichiometry of bromodomain-containing complexes in Trypanosoma cruzi using proximity labeling and structure prediction.

The paper reports the first live triatomine bug in Europe, found in a Lisbon hotel room, highlighting the risk of accidental importation of disease vectors.

This study presents a near-complete genome of Trypanosoma rangeli using hybrid sequencing, transcriptomics, and proteomics, revealing novel insights into its biology and evolution.

This paper identifies ZNK1 as a zinc-sensing RNA-binding protein in trypanosomes that degrades ZIP3 mRNA in response to zinc availability.

The paper shows that a combination of GNF6702 and benznidazole can cure experimental chronic Chagas disease with shorter treatment duration and fewer side effects.

This study identifies temperature-sensitive mRNA structures and shows that argonaute-dependent transcriptome remodelling mediates thermo-sensing in trypanosomes.

The paper reports high-resolution structures of T. cruzi glycolytic enzymes and identifies potential inhibitors through structural analysis and virtual screening.

This study investigates whether Trypanosoma cruzi-infected triatomine insects prefer mammalian hosts over non-mammalian ones, finding that infected T. gerstaeckeri show no host preference while uninfected ones prefer dogs.

This study shows that maternal Trypanosoma cruzi infection causes significant placental remodeling and systemic changes, regardless of whether the infection is transmitted to the fetus, and identifies potential biomarkers for prenatal monitoring.

This study shows that small heat shock proteins (sHSPs) in Rhodnius prolixus are critical for gut homeostasis and parasite control during Trypanosoma cruzi infection.

This paper identifies mutations in the gamma subunit of the mitochondrial ATP synthase in Trypanosoma brucei that lead to kinetoplast loss and drug resistance.

This study shows that mutations in the HKD motif of TbCls in Trypanosoma brucei disrupt cardiolipin synthesis and parasite growth.

The paper uses metagenomic sequencing and qPCR to detect Trypanosoma cruzi in bats from Belize, demonstrating their role as bioindicators for emerging zoonoses.

The paper identifies and characterizes the first RNA viruses in trypanosomes, including a leishmaniavirus and two narnaviruses in Trypanosoma platydactyli, suggesting ecological factors influence viral acquisition.

The paper identifies mutations in trypanosome CPSF3 that confer resistance to acoziborole, a drug targeting RNA processing, and explains the molecular mechanism of resistance through computational modeling.

This study shows that extracellular glutamine is critical for cell division and flagellar function in Trypanosoma brucei bloodstream forms, with its absence leading to polyploid, multiflagellated cells and proteome glutamylation changes.

The paper develops and tests a low-cost, point-of-need molecular xenomonitoring protocol for tsetse flies in a low-resource setting, achieving high DNA extraction success and pathogen detection rates.

This study investigates the evolutionary origins of host association and polycistronic transcription in trypanosomatids using comparative genomics across 47 genomes.