Carolina Duque

This study shows that maternal Trypanosoma cruzi infection causes significant placental remodeling and systemic changes, regardless of whether the infection is transmitted to the fetus, and identifies potential biomarkers for prenatal monitoring.

The paper sequenced clinical T. cruzi isolates, finding genomic instability and a unique antigen repertoire absent in lab-adapted strains.

This study identifies immune-related gene expression changes in asymptomatic Chagas cardiomyopathy patients, suggesting unique immune mechanisms in early disease progression.

This study shows splenic follicular B cells worsen heart failure after MI by presenting cardiac antigens via MHC II, promoting adverse cardiac remodeling.

The paper identifies B cell gene expression and interactions in healthy and diseased human myocardium, finding disease-specific changes in DCM and ARVC.