Trypanosoma species research and implications

This study identifies HGT-derived genes critical for sterol biosynthesis in trypanosomatids, showing how gene loss and retention during parasitism shape metabolic adaptations.

The paper engineers heat-stable variants of Tc24, a Trypanosoma cruzi antigen, enabling serological detection of Chagas disease without refrigeration.

This study shows slender Trypanosoma brucei can infect both teneral and non-teneral tsetse flies without supplements, and remains transcriptionally distinct from stumpy forms during differentiation.

This study evaluates a new Tc-24 recombinant antigen ELISA for detecting anti-T. cruzi antibodies in dogs, showing high sensitivity and specificity compared to existing tests.

The paper identifies TcIMPDH as a druggable target for Chagas disease and shows AVN-944 has potent inhibition and selectivity in infected cells.

This study determines the 3D structures of TcPOP in open and closed conformations using cryo-EM and evaluates its immunogenicity through antibody responses in mice.

This study compares gene expression in trypanotolerant and trypanosusceptible cattle during trypanosome infection across multiple tissues and time points, identifying immune-related and coagulation genes associated with trypanotolerance.

This study evaluates the vectorial competence of Glossina brevipalpis in transmitting Trypanosoma congolense-savannah type, finding it to be a competent biological vector.

This study examines how different heme sources affect gene expression in Trypanosoma cruzi, identifying novel heme-responsive genes and proteins.

The paper reports field evidence of Trypanosoma cruzi infection in Triatoma sanguisuga in Florida, showing human contact and potential for autochthonous Chagas disease transmission.

The paper genetically characterizes Trypanosoma brucei populations in pigs from Cote Ivoire, finding clonal and subdivided structures in Tbb that differ from previous studies.

This study shows Trypanosoma cruzi amastigotes scavenge cholesterol from host ER and Golgi through membrane contact sites and endocytosis, supporting their growth.

This study identifies phase-specific nuclear proteome changes in Trypanosoma cruzi during the cell cycle, revealing metabolic enzymes' role in nuclear processes.

This study shows that knocking out histidine ammonia-lyase in Trypanosoma cruzi prevents histidine metabolism, affecting energy production and parasite life cycle.

The paper develops synthetic glycan fragments of T. brucei GPIs to detect antibodies against the parasite, showing they elicit both IgM and IgG responses, enabling diagnostic tests for African trypanosomiasis and Nagana.

This study identifies a novel histone H4 variant (H4.V) in Trypanosoma cruzi, showing distinct genomic localization, expression profiles, and chromatin-binding dynamics compared to H2B.V.

This study shows that ATP synthase reversal, regulated by TbIF1, is essential for Trypanosoma brucei differentiation between insect and mammalian hosts.

The paper evaluates thio- and seleno-semicarbazones and their azole derivatives for treating African trypanosomiasis, finding Se derivatives more active than S analogues and highlighting the importance of combining TbrCATL inhibition with antioxidant activity.

The paper sequenced clinical T. cruzi isolates, finding genomic instability and a unique antigen repertoire absent in lab-adapted strains.

The paper investigates genetic differentiation between Glossina brevipalpis populations in two Mozambican National Parks, finding them to be isolated subpopulations with minimal gene flow.

The paper develops a new conditional gene expression system in Angomonas deanei using T7 RNA polymerase to enable genetic manipulations without interfering with endogenous transcription.

The paper investigates the genomic organization of tRNA genes in Trypanosoma cruzi, revealing synteny with Trypanosoma brucei and identifying chromatin insulator-like tRNA genes.

This study uses tagged tubulin to show that Trypanosoma brucei restricts microtubule assembly to the new flagellum during duplication but allows transient reassembly in mature flagella after cell division.

This study uses cryoEM to reveal the structure of the central apparatus in Trypanosoma brucei flagella, identifying PF16 as a key scaffold and uncovering lineage-specific adaptations.

This study examines MCM protein expression and localization in Trypanosoma cruzi during metacyclogenesis and G1 arrest, revealing their role in cell cycle regulation and replication arrest.

This study identifies TcCARP3 as a regulator of cAMP signaling in Trypanosoma cruzi, essential for osmoregulation, host cell invasion, and vector colonization.

This study identifies and characterizes mtTF1, a novel mitochondrial transcription factor in Trypanosoma brucei, showing its essential role in mitochondrial gene expression and parasite survival.

This paper shows that ATP-dependent phosphofructokinase (PFK) in Trypanosoma brucei functions gluconeogenically in vivo, challenging its traditional role in glycolysis.

This paper identifies TAC53 as a novel component of the Tripartite Attachment Complex (TAC) in Trypanosoma brucei, revealing its tubular architecture and role in mitochondrial DNA segregation.

The paper introduces a dual inducer system for RNAi complementation in Trypanosoma brucei, enabling independent and tunable regulation of gene expression to study kDNA replication.