Neurological disorders and treatments

This paper uses a computational model to show that combined electrical and ultrasonic stimulation reduces beta power in Parkinsonian brain networks more effectively than single modalities.

This study investigates thalamic dysrhythmia in Parkinsonism by comparing activity in dopamine-intact and 6-OHDA-lesioned rats, finding zone-selective abnormalities in the basal ganglia-recipient zone.

This study investigates the effects of deep brain stimulation (DBS) on cocaine self-administration in cocaine-dependent rats and finds it increases cocaine intake but raises GluR1 levels in the central nucleus of the amygdala.

This study identifies the neurophysiologic correlates of tremor onset and sustained tremor in Parkinson's disease using intraoperative recordings.

The paper develops a dual optimization algorithm to infer short-term synaptic plasticity dynamics in response to deep brain stimulation using a model-based approach and empirical data.

The paper investigates how dystonia-specific mutations in THAP1 affect gene transcription related to neurodevelopment and myelin in iPSC-derived neural cells and mouse models.

This study shows that the DYT-THAP1 mutation F81L impairs THAP1 transcriptional activity and disrupts CNS myelination by reducing YY1 DNA binding.

This study develops a closed-loop brain stimulation algorithm in parkinsonian rats that modulates beta oscillations by synchronizing stimulation with cortical activity cycles, leading to sustained changes in oscillation amplitude and locomotion.

This study investigates how specific neuronal pathways around the subthalamic nucleus affect gait in Parkinson's disease patients undergoing DBS, finding associations between pathway activation and step length changes.

The paper examines how stimulation location relative to grey and white matter affects single pulse electrical stimulation responses in the human brain, finding location and parameter-specific effects.

The paper maps functional domains and subnetworks in the cortico-basal ganglia-thalamic loop in mice, revealing complex patterns of convergence and divergence.

This paper develops a neurocomputational model of the basal ganglia to study motor deficits in early-stage Parkinson's disease by simulating dopaminergic loss and its effects on motor learning.

The paper shows that cerebellar stimulations reduce or prevent levodopa-induced dyskinesia in mice by normalizing brain activity and reversing neuronal plasticity.

This paper introduces an ultra-low frequency spike timing dependent plasticity-based electrical stimulation approach to reduce DMS D1/D2 MSN signaling imbalances and alcohol consumption in a mouse model of AUD.

The paper shows that subthalamic nucleus activity decreases during movement switches, challenging theories of movement suppression and revealing distinct neural coding for kinematics and action changes.

This study identifies convergent transcriptomic targets of propranolol and primidone in essential tremor, highlighting potential biomarkers and molecular mechanisms for drug response.

The paper investigates changes in the connectome of the A13 nucleus in Parkinson's disease models, finding widespread reconfiguration of afferent and efferent projections following nigrostriatal degeneration.

This study shows that PPN LFP alpha and beta oscillations are rhythmically modulated by gait phase, with spatial specificity and increased modulation in regular stepping.

This study investigates how Parkinson's disease affects basal ganglia output during movement preparation in mice, finding that internal goal-based movements are more impaired than stimulus-guided ones.

This study uses 7 T fMRI to test the tripartite model of subthalamic nucleus organization in healthy volunteers and finds no evidence for functionally distinct subregions.

The paper evaluates motor impairments and beta oscillations in a 6-OHDA rat PD model, finding high beta power as a biomarker and DBS as a performance enhancer.

This paper develops an algorithm for optimal closed-loop deep brain stimulation using multi-contact electrodes to maximize desynchronization of brain activity.

This study uses subcellular proteomics to show that DYT-TOR1A mutant cells have greater nuclear proteome disruption under stress compared to other conditions.

The paper characterizes cortico-basal ganglia neural activity under different sedation states and compares them to sleep states to inform asleep DBS.

The paper compares movement execution and observation in Parkinson's patients by analyzing oscillatory activity and coupling in the basal ganglia-thalamocortical circuit, finding that certain network features are specific to movement execution.

This paper uses thalamic deep brain stimulation in macaques to manipulate consciousness, finding that it induces absence-like activity with decreased neural complexity and integration, similar to absence epilepsy.

The paper introduces an open-source Matlab toolbox for processing and analyzing data from the Medtronic Summit RC+S neurostimulation system.

This paper shows that average beta burst duration profiles reflect changes in the dynamics of beta oscillations between ON and OFF medication states in Parkinson's disease, linking them to motor impairment.

The paper identifies Gabrr3-expressing neurons in the STN as critical for locomotion and OCD-like behaviors in mice, showing their potential for targeted therapeutic interventions.