Neurological disorders and treatments

The paper investigates abnormal network dynamics in the GPe-STN circuit of Parkinsonian mice and identifies key changes in neuronal activity and connectivity.

This study shows that Purkinje cell activity is essential for tremor, as silencing it blocks tremor in mice and modulating it with deep brain stimulation reduces tremor.

The paper examines deviations in directional DBS lead orientation from intended implantation directions in a patient cohort.

This study uses cortical network analysis to predict deep brain stimulation outcomes in dystonia patients, finding that grey matter atrophy patterns can predict response with 88% accuracy.

The paper uses whole genome sequencing to identify candidate genes for essential tremor in families, finding variants in CACNA1G and other genes associated with neuronal function and hereditary neuropathies.

This paper predicts the effects of deep brain stimulation using a reduced coupled oscillator model and proposes a hybrid strategy for closed-loop DBS in essential tremor patients.

The paper analyzes single neuron activity in the subthalamic nucleus of Tourette Syndrome patients during DBS procedures, finding higher bursting activity compared to Parkinson's Disease patients.

This study uses resting-state fMRI to show that deep brain stimulation (DBS) in Parkinson’s Disease modulates global brain connectivity, normalizing it toward healthy controls and altering specific network couplings.

This study identifies effective deep brain stimulation targets for essential tremor by analyzing structural and functional brain connectivity in patients.

This study examines beta burst dynamics in the cortico-basal ganglia network of PD patients and rats, showing phase relationships and rhythmic activity patterns that correlate with motor impairment.

This study shows that closed-loop DBS in Parkinson’s Disease can alter motor performance during specific movement intervals, particularly by increasing submovements and delaying movement termination.

The paper reports in vivo evidence of an ultradirect extra-thalamic pallido-cortical pathway in humans using the Human Connectome Project dataset.

This study identifies a thalamo-subthalamic pathway involved in movement initiation and shows that stimulating this pathway can rescue Parkinsonian symptoms in mice.

This paper develops a biophysical model of VIM to investigate how extrinsic and intrinsic oscillatory activity contribute to essential tremor.

This study examines how deep brain stimulation (DBS) and dopaminergic medication affect cortical activity and corticomuscular coherence in Parkinson’s disease patients using MEG and EMG.

The paper examines striatal oscillations in Parkinsonian non-human primates and finds increased alpha and low-beta band activity linked to dopamine loss and motor abnormalities.

The paper shows that beta waveform shape features distinguish Parkinson's Disease patients on and off medication using non-invasive scalp EEG.

This study examines how promised reward affects subthalamic nucleus activity during conflict resolution in Parkinson’s disease patients using local field potential recordings.

The paper uses LFP oscillations from the ventral striatum to predict feeding behavior in rats, finding an optimal balance between model complexity and performance.

This study investigates abnormal reward-learning in cervical dystonia using computational modeling and finds that decreased D2 cortico-striatal synaptic plasticity explains impaired reversal learning.

The paper identifies distinct cortical-thalamic-striatal circuits within the parafascicular nucleus in mice, revealing heterogeneous neurons organized into parallel functional subcircuits.

This paper uses computational modeling to show that symmetric biphasic DBS is more effective than standard DBS at reducing tremor frequency oscillations in the thalamus, with stronger effects on intrinsic networks.

The paper integrates multi-omics data to identify genes and pathways associated with essential tremor, finding dysregulated genes and enriched pathways in cerebellar regions.

This study investigates the neural mechanisms underlying transitions in cortical beta power in Parkinsonian rats using dynamic causal modeling and identifies key thalamocortical coupling patterns.

The paper develops a computational model of dopaminergic cell loss in Parkinson’s disease due to glutamate-induced excitotoxicity and evaluates therapeutic interventions.

This paper decodes voluntary movements and postural tremor from thalamic LFPs to enable on-demand DBS for essential tremor without peripheral sensors.

This study identifies white matter connectivity patterns associated with non-motor effects of subthalamic nucleus stimulation in Parkinson's patients.

This study investigates phase-amplitude coupling (PAC) in the subthalamic nucleus of Parkinson’s disease patients and finds that spiking activity synchronizes with high-frequency oscillations during PAC, correlating with beta burst duration.

The paper examines high gamma activity in the subthalamic nucleus and sensorimotor cortex during speech production, finding articulator-specific signals in both regions with similar timing but different topographical organization.

This study shows that phase-dependent electrical stimulation can suppress beta oscillations in Parkinson's patients, offering a potential therapeutic strategy.