Peripheral Artery Disease Management

This study shows that a stent designed to better accommodate limb-flexion deformation reduces inflammation and neointimal hyperplasia compared to a standard stent.

The paper finds a higher polygenic score for PAD is linked to younger age at surgery, replicated in UK Biobank.

This paper models foot perfusion during a cuff-induced ischaemia test to assess how arterial occlusions and collateral impairment affect tissue perfusion in different foot regions.

This study identifies genetic variants associated with lower extremity amputation risk in peripheral artery disease using GWAS from the All of Us Research Program.

This study characterizes the biomechanical properties of porcine lower limb arteries to evaluate their suitability as preclinical models for peripheral vascular devices.

This study identifies PAD-associated SNPs with stronger associations with surgical intervention than premature onset using UK Biobank data.

This study characterizes luminal gains and damage after balloon angioplasty in human femoropopliteal arteries with varying calcium burdens using imaging, histology, and mechanical testing.

The paper generates and validates a single-cell RNA-seq dataset to identify pathogenic endothelial metabolism in peripheral arterial disease, showing cell-type specific metabolic changes in CLTI.

This study identifies sex-specific mitochondrial dysfunction in endothelial cells of diabetic PAD patients, showing that MitoQ improves vascular function in females.

This paper develops a 6-minute limb function test for preclinical hindlimb ischemia models to assess muscular performance and hemodynamics, showing it detects therapeutic differences better than traditional measures.

This paper develops a polygenic score for peripheral artery disease (PAD) that improves risk prediction across diverse populations and identifies high-risk individuals for adverse limb events.

This paper evaluates plasma biomarkers for causal association with peripheral artery disease using Mendelian randomization, identifying 19 biomarkers with significant genetic evidence for causality.

The paper identifies a causal network controlling endothelial cell states in critical limb ischemia using transcriptomics data and cSTAR analysis.

The paper identifies a novel risk locus for PAD on 2q35 in Dominicans using admixture mapping and health systems data.