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The Central Coupler of ClpXP Controls Intersubunit Communication and Couples Intrasubunit Chemical Energy with Force Generation
Robert P. Sosa, Alfredo Jose Florez Ariza, JeongHoon Kim…·Carlos Bustamante
Q208A mutations in up to four subunits of the ClpX central coupler barely slow unfolded-substrate translocation but raise ATP spent per step, weaken force generation and can abolish GFP unfolding.
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