Ultrasound and Hyperthermia Applications

This paper demonstrates that transcranial ultrasonic stimulation (TUS) modulates saccadic eye movements in humans with high spatial and temporal precision, and shows that baseline GABAergic inhibitory tone predicts response variability.

This study shows that single-pulse megahertz-range focused ultrasound can evoke calcium signaling and dopamine release in cultured human dopaminergic neurons.

This study validates ultrasound-mediated gene therapy for Alzheimer's disease using PET imaging to track AAV delivery and therapeutic effects.

This paper introduces backscattering fULM (B-fULM) to improve 3D functional ultrasound imaging sensitivity by integrating microbubble amplitude with count-based localization.

This study shows that ultrasound-activated nanobubbles reduce tumor stiffness and enhance lipid nanoparticle delivery and immunotherapy efficacy.

The paper shows that unilateral TUS of early visual cortex suppresses contralateral visual responses, indicating online neuromodulatory effects and dose-dependent suppression.

This study quantifies microbubble-induced streaming across ultrasound frequencies using PIV, finding stronger streaming at lower frequencies than expected.

This study evaluates FUS-BRBO for retinal gene delivery, showing AAV.FUS.3 achieves 2.1-fold and 19.5-fold higher transduction than AAV9 in insonated and uninsonated retinas, respectively.

This paper demonstrates a method to track CAR-T cells in vivo using nanobubble-based contrast-enhanced ultrasound, showing effective visualization in both tumor-bearing and non-tumor-bearing mice.

This paper demonstrates the attachment of PEI-coated microbubbles to neutrophils using click chemistry and electrostatic interactions, enabling ultrasound-responsive targeted delivery without compromising cell viability or migration.

This paper shows that HIFU treatment causes anisotropic changes in liver tissue detectable via backscattering coefficient, linking energy delivery to tissue response for thermal lesion monitoring.

This study uses nanobubble-mediated proteomic sonobiopsy to identify molecular signatures of BBB opening and glioblastoma in mice, distinguishing tumor-specific biomarkers from those caused by BBB disruption.

This study shows that focused ultrasound with microbubbles can increase circulating tumor biomarkers in blood and CSF of a mouse DMG model, with enrichment varying by source, analyte type, and marker.

This study shows that non-invasive ultrasound stimulation of the human nucleus accumbens affects reward processing and learning, similar to deep brain stimulation.

This study shows that repeated BBB opening using LIPU reduces amyloid pathology in a mouse model of Alzheimer's disease.

This study investigates how tFUS affects cortical circuits through direct and indirect mechanisms by targeting different brain regions in rats.

This study shows that transcranial ultrasound can specifically modulate motor neurophysiology in the human corticospinal tract, with effects dependent on ultrasound pressure and white matter microstructure.

This study compares ultrasonic rewarming with a water bath for cryopreserved liver spheroids, finding faster rewarming times but mixed effects on viability.

This study shows that low-intensity focused ultrasound (LIFU) with specific frequency patterns can modulate dopamine release and astrocytic activity in the nucleus accumbens, with effects dependent on frequency and sex.

The paper investigates how ultrasound affects microparticle behavior in disturbed vascular vortices, showing microbubbles self-assemble and anchor to vessel walls, suggesting a new therapeutic strategy.

This study combines thermally ablative focused ultrasound with VEGFR2 blockade to enhance T cell-dependent anti-tumor immunity and synergize with checkpoint inhibition.

This paper introduces a wearable patch for non-invasive ultrasound neuromodulation and sleep recording, showing increased REM sleep duration and reduced latency in human subjects.

This paper introduces a low-cost brain phantom for testing noninvasive neuromodulation techniques, validated for LIFU and tDCS with accurate biophysical properties.

This paper develops a whole-brain model to study how transcranial ultrasound stimulation (TUS) induces functional changes in the brain, identifying two mechanisms that predict plasticity-driven effects.

This study investigates how varying ultrasound parameters affect neural activity in rat sciatic nerves, finding that cumulative energy exposure determines excitation or suppression of motor responses.

This study uses deep brain ultrasound to modulate visual attention by stimulating subcortical structures, showing site-specific effects on reaction time and search efficiency.

This study shows that repeated high-frequency tFUS exposure in non-human primates leads to neurodegeneration in stimulated and functionally connected brain regions, despite no behavioral disruption.

This study examines early microglial responses to FUS-induced BBB modulation, finding no significant density changes but increased cell elongation and altered synaptic interactions.

This study shows that transcranial ultrasound stimulation modulates neuronal membrane potentials in awake mice, with rapid depolarizations and entrainment effects.

This paper introduces an advanced transcranial ultrasound system that precisely modulates deep brain circuits with high spatial resolution and specificity.