Ultrasound and Hyperthermia Applications

Ultrasonic local anesthetic uncaging enables noninvasive, targeted, and transient knock-out of brain function

This paper demonstrates SonoRopi, a noninvasive method using ultrasound to transiently inhibit brain function in mice and rats.

A preclinical platform for focused ultrasound delivery from microplate to awake brain

This paper introduces a unified preclinical focused ultrasound platform validated across in vitro, ex vivo, and awake in vivo models for therapeutic applications.

Behavioral effects of targeting the central thalamus and pulvinar with transcranial ultrasound stimulation in healthy volunteers

This study uses tFUS to show that stimulating the central thalamus impairs vigilance and the pulvinar affects visuospatial attention in healthy volunteers.

MR-Guided Focused Ultrasound Neuromodulation of Nucleus Accumbens to Attenuate Oral Fentanyl Motivation in A Self-Administration Rat Model

This study evaluates MR-guided focused ultrasound targeting the nucleus accumbens to reduce fentanyl motivation in rats, finding no significant effect despite confirming NAc as the target.

Mitophagy is required for cell survival upon ultrasound and microbubble therapeutic exposure

This study shows that mitophagy is essential for cell survival after ultrasound and microbubble treatment by mitigating mitochondrial damage and metabolic stress.

Real-time ultrafast holography of focused ultrasound wave fields using an ultrasound scanner

This paper develops a real-time ultrafast holography method for imaging focused ultrasound fields using an ultrasound scanner, achieving accurate wave field reconstruction and dual-mode imaging.

Low-intensity ultrasound drives offline neuromodulation through passive membrane mechanisms in synaptically isolated hippocampal neurons

The paper shows low-intensity ultrasound alters passive membrane properties in hippocampal neurons without requiring synaptic receptors.

Membrane Filtration Removes Lipids and Compromises the Acoustic Stability of Nanobubbles

This study shows that membrane filtration removes more lipid from nanobubbles than size exclusion predicts, reducing their acoustic stability under ultrasound.

Development and Characterization of Ultrasound-Activated Polymeric Microdroplets for Targeted Chemotherapy

This paper develops ultrasound-activated microdroplets for targeted chemotherapy, showing high drug encapsulation and pressure-dependent release.

Dose-dependent ultrasound neuromodulation of the human brain

This study shows that ultrasound-induced tissue displacement predicts functional neuromodulation in the human brain during transcranial ultrasound stimulation.

Towards Quantitative In Vitro Modelling of Focused Ultrasound-mediated Blood-Brain Barrier Opening using an Ultrasound-transparent Organ-on-Chip Device

This study develops an ultrasound-transparent organ-on-chip device to quantitatively model FUS-mediated BBB opening and assess the effects of acoustic exposure and bubble activity.

Acoustically activatable drug-loaded nanodroplets for mechanochemical therapy in solid tumors

This paper develops acoustically activatable nanodroplets for targeted drug delivery and mechanical tumor disruption, showing improved tumor control and survival in vivo.

Ultrasound-activated drug release with extracellular vesicles

This paper develops ultrasound-responsive extracellular vesicles for targeted drug delivery to the nervous system, demonstrating controlled release and pain modulation in rats.

Histotripsy-induced vascular remodeling in the tumor microenvironment enhances local and off-target intratumoral drug delivery

This study shows histotripsy induces vascular remodeling in tumors, improving perfusion and drug delivery, and enhances immune cell infiltration.

Focused Ultrasound Neuromodulation of the Central Lateral Thalamus in a Non-Human Primate Model of Disorders of Consciousness

This study investigates focused ultrasound neuromodulation of the central lateral thalamus in a non-human primate model of disorders of consciousness, finding no significant changes in arousal but suggesting distributed network stimulation may be more effective.

An electronically steerable epidural ultrasound interface for deep brain neuromodulation in freely moving rats

This study presents an implantable epidural ultrasound device for chronic, steerable neuromodulation in rats, showing increased dopamine release and no significant inflammation.

Nonviral, ultrasound-triggered gene delivery platform via gas-core cationic nanobubbles

This paper develops a nonviral, ultrasound-triggered gene delivery platform using cationic nanobubbles that achieve efficient, site-specific gene expression in vitro and in vivo.

Noninvasive Focal Gene Delivery of Functional Neural Actuators to the Primate Spinal Cord using Focused Ultrasound

This paper demonstrates noninvasive, focal gene delivery to the primate spinal cord using focused ultrasound, showing functional transgene expression and preserved neurological function.

Ultrasonic Reporter of Kinase Activity

This paper introduces an ultrasonic reporter of kinase activity (UReKA) to monitor PKA activity in opaque tissues by altering ultrasound scattering of gas vesicles.

Dose-Dependent Effects of Low-Intensity Focused Ultrasound on Human Deep White Matter Tracts

This study examines dose-dependent functional connectivity changes in healthy adults after low-intensity focused ultrasound (LIFU) targeting deep white matter tracts.

Low-intensity focused ultrasound pulsation along the anterior-posterior thalamic axis differentially modulates the latency of reporting conscious visual experience

This study shows that thalamic LIFU affects the latency of reporting conscious visual experience, with effects varying by target location and acoustic parameters.

Neurobehavioral effects of focused ultrasound-mediated blood-brain barrier opening

This study evaluates the neurobehavioral effects of MB-FUS in rats, showing dose- and target-dependent adverse effects on behavior and brain tissue.

Systemic Nanobubbles Enable Ultrasound-Guided STING Immunotherapy in Breast Cancer

This paper develops SONATA, a nanobubble-based ultrasound-guided immunotherapy that activates the STING pathway in breast cancer, showing tumor growth inhibition and improved survival in mice.

Simulation-guided non-thermal low-intensity ultrasound reprograms the tumor immune microenvironment and engages systemic antitumor immunity in a syngeneic orthotopic mouse model of breast cancer

This paper investigates the effects of non-thermal low-intensity ultrasound on tumor biology and immune response in a mouse breast cancer model, showing reduced tumor growth and immune system activation.

Development of Visually Indistinguishable Acoustic Coupling Pads for Double-Blind Focused Ultrasound Neuromodulation Studies

This paper develops and validates visually and mechanically indistinguishable acoustic coupling pads for double-blind tFUS studies, achieving precise control over ultrasound transmission and blocking.

Preclinical Evaluation of Molecular-Targeted Ultrasound Contrast Agents in a Rabbit Model

This study evaluates PSMA-targeted nanobubbles in a rabbit model to improve prostate cancer detection via ultrasound, showing enhanced tumor targeting and retention compared to conventional microbubbles.

Ultrasonic potentiation of ketamine neuromodulation

This paper shows that focused ultrasound enhances ketamine's neuromodulatory effects, with localized delivery via SonoKet achieving greater neurotransmitter changes at lower doses.

Psychophysical validation of calibrated white-noise and tuned-noise auditory masks for transcranial focused ultrasound

This study validates auditory noise masks to reduce the perceptibility of transcranial ultrasound, finding that high masker levels are needed and spectrum-tuned masks do not outperform white noise.

Effects of transcranial focused ultrasound stimulation to human lateral geniculate nucleus on visual perception and steady-state visual evoked potentials

This study investigates the effects of transcranial focused ultrasound on visual perception and SSVEP in humans but finds no significant impact despite accurate targeting.

Focused Ultrasound Thermal Ablation and CD40 Agonism Reprograms Breast Tumor Immunity to Drive Regression and Memory

This study shows that combining focused ultrasound thermal ablation with CD40 agonism enhances tumor immunity, leading to durable regression and immunological memory in breast cancer models.