Olfactory and Sensory Function Studies

The paper investigates how mice generalize responses to odorant mixtures by testing models that predict perceptual similarity based on molecular nearest neighbors.

This study characterizes retronasal olfactory habituation and its impact on flavor perception through two experiments with food and non-food odors.

This study shows that OMP deletion leads to functional and anatomical heterogeneity in olfactory glomeruli due to anomalous co-innervation by OSNs with different ORs.

The paper compares olfactory preferences across flies, mice, and humans, finding positive correlation between flies and mice, negative correlation between flies and humans, and no evidence of shared preferences between humans and mice.

This paper trains an autoencoder to represent odorant chemical space and uses it to predict human olfactory percepts with accuracy comparable to traditional molecular descriptors.

The paper shows that odor concentration discrimination is independent of sniff frequency, and a fluid dynamics model explains variability in MT cell responses, enabling sniff-invariant coding.

The paper investigates state-dependent changes in olfactory cortical networks by examining the balance of bottom-up and top-down synaptic inputs in freely moving rats.

This study shows that complement 3 signaling via CR3 is necessary for the proper development and refinement of olfactory bulb maps.

The paper shows that recurrent cortical circuits maintain odor identity coding despite concentration changes by suppressing concentration-dependent inputs.

The paper shows that mice use olfactory bulb mitral and tufted cells to encode inhalation dynamics, enabling odor intensity perception independent of sniffing variability.

This study develops an automated odor discrimination task for adult zebrafish, showing they can rapidly learn fine odor discriminations through conditioned feeding behavior.

The paper shows that single olfactory receptors, specifically TAARs, set odor detection thresholds in mice, with sensitivity determined by the most sensitive receptor.

This study shows that Ano2 clamps odor-evoked spike activity in olfactory receptor neurons in vivo, despite reduced transduction currents in Ano2-/- mice.

The paper identifies unique molecular markers for GC-D+ olfactory sensory neurons and Grueneberg ganglion chemosensory neurons and their target glomeruli in mice.

The paper demonstrates that extrasynaptic glutamatergic signaling in olfactory bulb glomeruli creates a thresholding effect by balancing excitation and inhibition, allowing only strong stimuli to produce an output.

The paper proposes a compressed sensing algorithm in the mammalian main olfactory bulb using computational modeling and electrophysiological data, showing it can efficiently represent odors and adapt to odor mixtures.

The paper shows that active sampling state enhances odor representation in the olfactory bulb during rapid learning.

The paper tests a model predicting that granule cell excitability drives beta oscillations in the olfactory bulb through voltage-dependent calcium channels, using pharmacological manipulations.

The paper investigates age-related olfactory loss by analyzing cytokine levels in human olfactory mucus and their association with olfactory function decline.

The paper predicts perceptual ratings for odorants using natural language semantics and chemoinformatic features, achieving higher accuracy for more descriptors than previous methods.

The paper analyzes odorant-receptor interactions using a kinetic model to characterize OR activation statistics and their implications for odor perception.

The paper maps zonal expression of olfactory receptors in mouse MOE using mRNA sequencing, identifying zones for 1,033 OR genes with high coverage and accuracy.

The paper models how mammalian olfactory receptor neurons process odor mixtures, showing antagonistic interactions lead to normalization of glomerular responses and improve odor discrimination.

This study shows that olfactory fear conditioning enhances glomerular odor responses and increases similarity between learned and neutral odors, potentially promoting fear generalization.

The paper shows that sister MT cells in a glomerulus exhibit diverse or stereotyped responses to odorants, with stereotypy linked to ligand affinity regardless of concentration.

The paper models how piriform cortex transforms temporal latency coding from the olfactory bulb into ensemble coding, showing robust odor representation across concentration changes.

The paper investigates how inhalation frequency affects odor representations in mitral/tufted cells of the olfactory bulb, finding frequency-dependent changes in neural activity patterns.

This study identifies shared genetic requirements for ATF5 translation in vomeronasal and olfactory sensory neurons, showing similar regulation by the unfolded protein response.

This study shows that rats can selectively attend to odors amidst competing stimuli, improving odor-guided decisions and sharpening neural representations of odors.

This study investigates the functional role of the cortico-striatal pathway from the piriform cortex to the olfactory tubercle in mice, showing it modulates odor coding through monosynaptic connections.