Olfactory and Sensory Function Studies

This paper develops a deep learning model called MolOR to predict odor percepts from odorant molecules by leveraging olfactory receptor activation profiles, showing improved prediction despite limited data overlap.

The paper shows that mice can discriminate odors in complex mixtures primarily limited by neural sensitivity rather than background complexity.

The paper uses genome sequencing data and machine learning to identify genetic factors associated with anosmia and ageusia in COVID-19 patients.

The paper presents an ensemble model that improves predictions of perceptual similarity between odor mixtures using a curated dataset and collaborative challenge results.

This study investigates how environmental olfactory exposures affect cell-type specific transcriptional responses in the mouse main olfactory epithelium using single-cell RNA sequencing.

This study examines the effects of acute hypoxia on the olfactory system of zebrafish, revealing degenerative and regenerative responses in the olfactory epithelium and bulb.

The paper identifies a non-monotonic concentration-response relationship in mitral/tufted cells of the mouse olfactory bulb, suggesting interglomerular inhibition facilitates odor discrimination.

The paper uses lineage tracing to differentiate olfactory and vomeronasal neurons from GnRH-1 and terminal nerve neurons, revealing genetic heterogeneity and additional olfactory placode-derived cells in the brain.

This study shows that Cnpy1 is essential for V2R processing and transport in basal vomeronasal sensory neurons, with its loss causing functional impairment and circuit disruption.

The paper examines how experience transforms olfactory representations along the cortico-hippocampal pathway in mice, showing increased odorant selectivity and population-level representations in hippocampal structures.

This study uses snRNA-seq to identify distinct neuronal responses in the amygdala to dominant and subordinate olfactory cues, revealing specialized glutamatergic and GABAergic populations.

The paper investigates how odor information is routed through feedforward and feedback pathways in the mouse olfactory cortex, finding distinct temporal encoding and plasticity in neurons projecting to different targets.

This study shows that unilateral odor stimulation in Xenopus tadpoles leads to bilateral glomerular potentiation mediated by dopamine, compensating for imbalances in olfactory sensory neuron activity.

This study shows that synaptic inhibition in the accessory olfactory bulb is crucial for pheromone location learning and memory in rodents.

The paper shows that olfactory receptor expression in the nose follows a spatial code controlled by a retinoic acid gradient, aligning epithelial and brain maps.

This study investigates how mice perceive intermittent odor stimuli by analyzing behavioral responses and neural activity in the anterior piriform cortex, finding that respiratory phase modulates perception but limits information acquisition.

This study shows that odor representation in the piriform cortex of mice changes over time with experience and is modulated by odor investigation behavior.

This study shows that olfactory fear conditioning in mice leads to heritable changes in olfactory neuron frequencies and behavior across generations.

This study shows chronic stress increases microglial complexity in the anterior piriform cortex, correlating with odor avoidance behavior in mice.

This study characterizes the expanded olfactory receptor gene repertoire in Senegalese sole, identifying 455 genes and showing functional expression through transcriptome analysis.

This study shows that efficient coding recovers canonical olfactory features by maximizing mutual information layer-wise under biophysical assumptions.

This study shows that olfactory learning with odor mixtures transfers across nostrils and to dissimilar odors, while learning with enantiomers does not, indicating distinct processing stages for concentration ratio and chirality.

The paper examines electrophysiological features of ACo neurons during an odor-guided task, revealing distinct patterns of odor and reward anticipation.

The paper investigates glutamatergic heterogeneity in neuropeptide projections from the lateral hypothalamus to the mouse olfactory bulb, finding distinct VGLUT expression patterns in orexin-A and MCH axon terminals.

This paper introduces a method to quantify approach/avoidance behavior in mice across multiple odors using information theory and demonstrates its application in fear conditioning experiments.

The paper introduces an odor sampling bag system that improves odorant concentration control and reliability compared to traditional methods.

This study examines long-term taste dysfunction in Long COVID patients, finding that while most have mild issues, some lose specific taste qualities linked to reduced PLCβ2 and Tas1R3 expression without major structural damage.

This study investigates how the psychedelic drug DOI affects olfactory search behavior in mice, finding decreased search accuracy, altered movement, and increased sniff rate.

This study shows that blocking retro nasal pathways reduces neural and subjective responses to sucrose taste, suggesting retro nasal sensations contribute to taste perception.