Olfactory and Sensory Function Studies

This study shows that olfactory bulb activity synchronizes limbic circuits in the beta frequency range during neonatal development, shaping communication in the lateral entorhinal cortex, hippocampus, and prefrontal cortex.

This study records electrophysiological properties of human olfactory sensory neurons using acute slices, revealing functional transduction mechanisms involving cAMP.

The paper identifies odorant antagonists that reduce perception of malodors by interacting with olfactory receptors.

This study shows that natural and pathological aging differently affect the vomeronasal system and social behavior in mice.

The paper identifies a molecular-level representation of odors that predicts receptor, neural, and behavioral responses across species and shows metabolic relationships in odor space.

This study identifies a shared role for mec-2 and Stoml3 in olfactory behavior across C. elegans and mice, showing that they are required for odor discrimination but not odor detection.

This study identifies Arc-expressing interneurons in the accessory olfactory bulb that contribute to chemosensory social behavior plasticity through increased excitability and chemogenetic manipulation.

The paper uses semantic descriptors from language to predict odor mixture discriminability, outperforming existing methods by leveraging human perception data.

The paper identifies long-range GABAergic inhibitory feedback from cortical areas to the olfactory bulb, showing its role in modulating sensory processing and odor discrimination.

The paper presents a computational model of structural plasticity in the olfactory bulb that explains odor-specific subnetwork formation and differential learning effects during odor exposure.

This study examines how sex separation affects gene expression in the rabbit vomeronasal organ, revealing sex- and stage-specific plasticity in response to environmental changes.

The paper shows immature olfactory sensory neurons provide distinct odor input to the olfactory bulb, contributing to odor detection and discrimination tasks.

The paper uses high-throughput sequencing to analyze neuronal projections in the mouse olfactory system and finds structured connectivity along the anterior-posterior axis.

The paper identifies a non-canonical feedforward pathway for odor recognition mediated by tufted cells in the olfactory bulb, challenging the traditional role of the piriform cortex.

This study shows that mediodorsal thalamus neurons in alert rats dynamically encode intraoral olfactory and gustatory signals, including odor-taste mixtures and taste palatability.

The paper uses pseudotime analysis of single-cell RNA-Seq data to identify regulatory factors involved in the transition from multigenic to monogenic odorant receptor expression in mouse olfactory neurons.

The paper shows that AP-2ε reprograms vomeronasal sensory neurons and their behaviors by controlling gene expression, bypassing cellular plasticity restrictions.

The paper describes an ex vivo platform using olfactory cilia to functionally profile human odorant receptors with high sensitivity and scalability.

The paper maps odorant sensitivities in the mouse olfactory bulb, revealing a sparse and structured representation of olfactory chemical space through glomerular tuning properties.

This study shows that olfactory decoding accuracy in specific brain regions correlates with immediate food intake but not long-term weight change in sated humans.

This paper develops a behavioral paradigm to measure perceptual distances in mice using olfaction as a model system.

The paper shows that D1 and D2 neurons in the olfactory tubercle represent odor valence differently, with D1 neurons encoding valence broadly and D2 neurons encoding odor identity more specifically.

This study shows that mouse olfactory bulb projection neurons encode temporal odour frequency features up to 20 Hz, with coupling influenced by circuit properties.

This study identifies a prefrontal-olfactory network involved in olfactory selective attention, showing coordinated activity in mPFC and olfactory regions during attention shifts.

This study examines the long-term effects of SARS-CoV-2 on the olfactory system in Syrian golden hamsters, revealing persistent neuronal and glial changes.

The paper develops a model to predict odorous molecules based on chemical properties and estimates the number of possible odorous compounds to be over 30 billion.

This study investigates how the olfactory bulb processes binary odor mixtures under different brain states in awake mice, finding that mixture representation is state-dependent but not strictly correlated with summation linearity.

The paper demonstrates that top-down feedback to the olfactory bulb allows the olfactory cortex to switch between temporal and combinatorial coding strategies, improving odor discrimination performance.

This paper creates a 3D spatial transcriptomics atlas of the mouse olfactory mucosa, revealing spatial gene distribution patterns and supporting the chromatographic theory of olfaction.