Olfactory and Sensory Function Studies

The paper shows that Cl- efflux, not Na+ influx, provides a more reliable and robust signal amplification mechanism in vertebrate olfactory receptor neurons.

This study characterizes retronasal olfactory habituation and its impact on flavor perception through two experiments with food and non-food odors.

This study shows that OMP deletion leads to functional and anatomical heterogeneity in olfactory glomeruli due to anomalous co-innervation by OSNs with different ORs.

The paper compares olfactory preferences across flies, mice, and humans, finding positive correlation between flies and mice, negative correlation between flies and humans, and no evidence of shared preferences between humans and mice.

The paper shows that odor concentration discrimination is independent of sniff frequency, and a fluid dynamics model explains variability in MT cell responses, enabling sniff-invariant coding.

The paper shows that recurrent cortical circuits maintain odor identity coding despite concentration changes by suppressing concentration-dependent inputs.

The paper shows that mice use olfactory bulb mitral and tufted cells to encode inhalation dynamics, enabling odor intensity perception independent of sniffing variability.

This study develops an automated odor discrimination task for adult zebrafish, showing they can rapidly learn fine odor discriminations through conditioned feeding behavior.

The paper shows that single olfactory receptors, specifically TAARs, set odor detection thresholds in mice, with sensitivity determined by the most sensitive receptor.

This study shows that Ano2 clamps odor-evoked spike activity in olfactory receptor neurons in vivo, despite reduced transduction currents in Ano2-/- mice.

The paper shows that active sampling state enhances odor representation in the olfactory bulb during rapid learning.

The paper tests a model predicting that granule cell excitability drives beta oscillations in the olfactory bulb through voltage-dependent calcium channels, using pharmacological manipulations.

The paper analyzes odorant-receptor interactions using a kinetic model to characterize OR activation statistics and their implications for odor perception.

The paper maps zonal expression of olfactory receptors in mouse MOE using mRNA sequencing, identifying zones for 1,033 OR genes with high coverage and accuracy.

The paper models how mammalian olfactory receptor neurons process odor mixtures, showing antagonistic interactions lead to normalization of glomerular responses and improve odor discrimination.

This study shows that olfactory fear conditioning enhances glomerular odor responses and increases similarity between learned and neutral odors, potentially promoting fear generalization.

The paper shows that sister MT cells in a glomerulus exhibit diverse or stereotyped responses to odorants, with stereotypy linked to ligand affinity regardless of concentration.

The paper models how piriform cortex transforms temporal latency coding from the olfactory bulb into ensemble coding, showing robust odor representation across concentration changes.

The paper investigates how inhalation frequency affects odor representations in mitral/tufted cells of the olfactory bulb, finding frequency-dependent changes in neural activity patterns.

This study identifies shared genetic requirements for ATF5 translation in vomeronasal and olfactory sensory neurons, showing similar regulation by the unfolded protein response.

The paper identifies a concentration-invariant odor coding mechanism based on early receptor activation and demonstrates its role in odor identification through behavioral and neural experiments.

The paper introduces SMELL-S and SMELL-R, olfactory tests that reduce bias from odor-specific insensitivity and prior experience by using unfamiliar odorant mixtures, showing high reliability across populations.

The paper investigates how granule cells in the olfactory bulb influence mitral and tufted cells through inhibitory synchrony, finding that this effect occurs over distances up to 300 micrometers.

The paper examines the projection patterns of SL and SP neurons in the APC, revealing distinct axonal connections to downstream structures and a hierarchical feedback circuit.

The paper investigates experience-dependent plasticity in accessory olfactory bulb interneurons following male-male social interaction, showing increased intrinsic excitability in Arc-expressing interneurons leads to reduced mitral cell activity.

The paper demonstrates that machine learning can accurately predict odor perception from molecular features, enabling reverse-engineering of smell.