Sleep and Wakefulness Research

This study investigates the effect of optogenetic activation of GABAergic TRN neurons on sleep architecture in mice, finding no significant changes in sleep state durations or delta wave power.

This study identifies a cholinergic mechanism regulating sleep in the jellyfish Cassiopea, showing that Chrnal-E promotes wakefulness and its expression changes with sleep deprivation.

This study investigates the role of preoptic glutamatergic neurons in REM sleep regulation, finding they suppress REMs and disrupt sleep homeostasis when activated.

The paper examines cortical acetylcholine dynamics during behavioral state transitions, finding that axon activity and behavior predict ACh levels.

This study uses M/EEG to characterize theta-band activity during REM sleep, comparing it to working memory task-induced theta and identifying distinct spatial and frequency patterns.

This study shows that vibration-induced sleep in Drosophila improves learning, memory, and clearance of harmful proteins associated with Alzheimer's disease.

The paper develops a neural network model, Sleep Interpreter (SI), to decode memory replay from sleep EEG and shows it can accurately detect reactivation during sleep that correlates with memory performance.

This study shows that targeted memory reactivation during REM sleep reduces emotional responses by decreasing brain activity and physiological arousal to emotional stimuli.

The paper examines cardiac responses to auditory irregularities during sleep, showing slowed cardiac activity to global deviants in REM sleep and cardiac acceleration in light NREM sleep, indicating hierarchical information processing variations.

This study shows that reducing SWS or REM by 50% does not impair memory consolidation and may even improve psychomotor vigilance and procedural skills.

This paper investigates predictive processing during sleep by analyzing neural responses to predictable and random tones using EEG and MEG, finding that predictive patterns fade as sleep progresses.

This study examines the effects of TAAR2-9 knockout on sleep/wake patterns in mice, finding altered REM sleep and wakefulness but no difference in homeostatic response to sleep loss.

This study shows that TAAR1 partial agonism increases wakefulness and reduces NREM sleep in mice, with D1R and D2R antagonists modulating these effects differently.

This study investigates neural reactivation during REM sleep in mice, finding that novel and anxiety-related experiences shape distinct patterns of hippocampal assembly reactivation and sequence replay.

This paper develops a predictive model for sleep slow oscillation (SO) occurrences during NREM sleep, enabling more precise targeting for brain stimulation by analyzing SO timing and decay patterns across sleep cycles.

This study uses closed-loop auditory stimulation in mice to enhance slow-wave activity, improving sleep quality in Alzheimer's and Parkinson's disease models.

This paper introduces a seven-day sleep disturbance protocol using novel objects to minimize stress in mice and demonstrates its effectiveness and reduced stress compared to existing methods.

This study shows that closed-loop auditory stimulation can modulate alpha and theta oscillations during REM sleep in a phase-dependent manner, altering power and frequency.

The paper uses computational models to explore synaptic dynamics during the sleep-wake cycle, finding that wake-like firing patterns decrease synaptic weights while sleep-like patterns increase them, offering a unified framework for synaptic homeodynamics.

This study shows that during REM sleep, the mouse brain issues motor commands that shift internal direction representations, simulating actions and their consequences without physical execution.

This study shows that TRPV4 knockdown improves fear memory deficits caused by acute sleep deprivation by reducing Ca2+ overload and restoring synaptic plasticity.

This paper identifies novel neural markers of sleep depth using auditory arousal threshold instead of conventional sleep stages, revealing unique brain network correlations.

This study shows that scheduled feeding improves sleep patterns in male but not female Huntington's disease mouse models.

This study shows sleep deprivation reduces excitatory synapse diversity in the cortex and hippocampus of mice, while maintaining total synapse density.

This study investigates the role of sleep in motor skill maintenance through experiments showing sleep enhances memory retention when training occurs before bedtime.

This study weakens aversive memories during sleep by reactivating positive memories, reducing recall and increasing positive memory intrusions.

The paper identifies a distinct neuronal subpopulation in the retrosplenial cortex that fires during slow-wave sleep Down states and is involved in memory consolidation.

This study identifies CaMKII-dependent activity of cortical parvalbumin neurons as essential for homeostatic sleep rebound following prolonged wakefulness.