Sleep and Wakefulness Research

This study investigates the laminar profiles of sleep spindles in humans using EEG and microelectrode recordings, finding no strong association between spindle types and laminar profiles.

The paper shows that sleep is necessary for memory consolidation and synaptic remodeling in C. elegans after odor training.

The paper identifies a novel zebrafish sleep mutant, dreammist, and shows that disruption of a sodium pump regulator affects sleep duration through altered sodium homeostasis.

This study shows that targeted memory reactivation during slow-wave sleep improves performance in a serial reaction time task, particularly for the non-dominant hand, while REM sleep does not provide similar benefits.

The paper shows that astroglial calcium signaling in Drosophila increases with sleep need and is required for homeostatic sleep rebound, identifying TyrRII as a key receptor involved in this process.

This study examines how cerebral hemodynamics change during different sleep states in mice, finding that hemodynamic responses during NREM and REM sleep are significantly larger than those evoked by sensory stimulation.

The paper shows that sleep spindles during NREM sleep mediate corticostriatal plasticity, which is critical for the emergence of automatic behavior following training.

This study uses microarray analysis to identify differentially expressed genes in brain and liver tissues of rats after 9 days of REM sleep deprivation, finding distinct gene impacts in each tissue.

This study shows that NMDA receptors in the hypothalamus are critical for stabilizing NREM sleep and enabling REM sleep by regulating calcium signals and neural activity.

This study shows that sleep deprivation impairs the ability to suppress unwanted memories, leading to increased negative affect and potentially contributing to psychiatric conditions.

This study investigates how time of day affects generalization ability, finding better performance in the morning than the evening, with no benefit from sleep.

This study shows that suppressing REM sleep increases negative affect and amygdala responses to social exclusion the next day, but not emotional regulation through reappraisal.

This study shows that IGF-I modulates sleep by regulating orexin neurons in the hypothalamus, affecting sleep architecture and electrocorticographic patterns in mice.

The paper identifies SuML-DG neurons that modulate theta and gamma oscillations in the dentate gyrus during REM sleep and other vigilance states.

This study shows that sleep supports spatial learning in Drosophila, with sleep loss and aging impairing learning, which can be reversed by enhancing sleep.

The paper examines sleep-wake regulatory nuclei in rats using long-term single- and multi-unit recordings, finding differences in activity profiles compared to previous studies when correlated with cortical and behavioral data.

This study identifies AANAT1's role in astrocytes to regulate sleep homeostasis by modulating monoamine levels and rebound sleep after deprivation in Drosophila.

The paper quantitatively distinguishes sleep functions in development, showing an abrupt transition from neural reorganization to repair between 2-3 years in humans.

This study identifies hypothalamic circuitry involved in stress-induced insomnia and immunosuppression using genetic and optogenetic approaches.

This study examines the interaction between cortical slow oscillations and hippocampal ripples during sleep using a computational model and human recordings, finding that ripples influence cortical spatiotemporal patterns and synchronize state transitions.

The paper investigates high frequency oscillations during NonREM sleep, finding that fast oscillations are associated with memory consolidation after learning, while slow oscillations are not.

This study identifies MEF2C as essential for the biological responses to sleep loss, including gene expression changes and synaptic strength recovery.

This study shows that sleep-dependent gains in visual perceptual learning are better explained by a learning-dependent model than a use-dependent model.

This study shows that sleep replay helps protect old memories from being lost when new memories are learned, by reorganizing synaptic connections to support both memories.

The paper shows sleep loss disrupts hippocampal memory consolidation by activating somatostatin interneurons and cholinergic inputs, which inhibit memory-related activity.

The paper identifies the 1/f spectral slope as an electrophysiological marker that distinguishes wakefulness from sleep and anesthesia by reflecting changes in excitation-inhibition balance.

The paper examines how learning and sleep affect ribosomal mRNA profiles in hippocampal neurons, finding that sleep loss disrupts post-learning transcript changes more in active neurons.

The paper investigates how sleep spindles facilitate hippocampal-neocortical communication during sharp-wave ripples, showing increased coupling and directional influence from neocortex to hippocampus.

The paper identifies a SNP in the HOMER1 gene associated with sleep latency and theta power in sleep EEG in a Brazilian population.