Sleep and Wakefulness Research

This study shows seizures impair REM sleep by disrupting cholinergic neurons in the pedunculopontine nucleus in a mouse model of Dravet Syndrome.

The paper investigates how concurrent memory reactivation with odors and sounds during sleep affects memory consolidation, finding that some odors disrupt sound-induced memory benefits.

The paper investigates how sleep spindle and theta activity after trauma predict fewer intrusive memories, suggesting these oscillations protect against trauma-related memory formation.

This study investigates brainwide dopamine dynamics across sleep-wake transitions in mice using fiber photometry and EEG/EMG, revealing region-specific changes and network correlations.

This study identifies distinct sleep sub-states in larval zebrafish using behavioral data and Hidden Markov Modeling, showing their regulation by neuromodulators and conservation across vertebrates.

This study examines the asynchronous recovery of brain activity after awakening from deep NREM sleep, finding that frontal regions recover faster than posterior regions.

The paper examines how insufficient sleep affects tonic REM sleep EEG components and their associations with mood, cognition, and cortical excitability.

Loss of CACNA1G disrupts sleep rhythms and gene regulation, creating a mismatch between brain state and behavior linked to schizophrenia.

This paper develops a computational model that explains sleep-wake transitions and sleepiness through circadian-modulated thresholds, showing how circadian and homeostatic drives interact dynamically.

This study identifies cell-type- and region-specific transcriptional changes in non-neuronal cells of the mouse hippocampus and prefrontal cortex following acute sleep deprivation.

This study identifies three distinct sleep states in Drosophila and shows that homeostatic and circadian regulation of sleep is obscured when sleep is treated as a single state.

The paper introduces GENTIS, a genetically encoded ionic-stress sensor, and shows that proton accumulation drives sleep in C. elegans through v-ATPase inhibition and membrane disassembly.

This study examines the infraslow fluctuation of sigma power during sleep across development, finding it persists with increasing frequency and strength from childhood to young adulthood.

The paper investigates sleep firing rate homeostasis in a nonhuman primate model of Parkinson's disease and finds it is disrupted in parkinsonism.

This study examines how modafinil affects brain activity in rats during wakefulness and sleep, finding increased gamma-band power and altered sleep patterns.

The paper identifies a REM sleep-specific hypothalamo-septo-hippocampal circuit essential for social memory consolidation, showing its distinct role from other memory pathways.

The paper introduces RnB, a wavelet-based method to separate rhythmic and arrhythmic components in sleep EEG data, improving time-domain analysis of NREM sleep oscillations.

The paper identifies beat-Ia/CADM2 as a gene involved in hypersomnia by showing its role in sleep regulation across species and demonstrates potential therapeutic targets.

This study examines if sleep deprivation impairs motor learning and whether exercise can mitigate its effects, finding specific vulnerabilities and mixed exercise benefits.

This study investigates how sleep spindle clustering and coupling with slow oscillations affect motor memory consolidation and generalization through sensorimotor restriction.

This study identifies the median preoptic nucleus as a key site where estradiol regulates sleep-wake behavior in female rats, showing sex-specific effects and receptor-dependent mechanisms.

The paper uses polygenic risk scores and Mendelian randomization to show circadian genetic factors contribute to idiopathic hypersomnia.

This paper characterizes vigilance-state transitions in mice using EEG-EMG data and validates a machine learning approach to detect transition midpoints.

The paper re-analyzes sleep deprivation and recovery gene expression data to identify somatostatin-expressing neurons as potentially key regulators of sleep behavior.

This study compares fractal dynamics between phasic and tonic REM sleep states using EEG data and finds distinct spatiotemporal patterns despite similar global complexity.

This study investigates memory reactivation during sleep using targeted memory reactivation, finding faster reactivation and an inverted-U relationship between encoding strength and memory improvement.

The paper investigates whether slow spindle trains during daytime naps support declarative memory consolidation, finding that slow spindles clustered in trains correlate with better memory performance.

The paper investigates coordinated infraslow cortical oscillations of multiple neuromodulators during NREM sleep in mice and finds they are regulated by specific neural circuits.

This study investigates how ischemic lesions disrupt sleep-related cortical activity across multiple scales in rats, revealing stage-specific alterations in sleep-wake cycle dynamics and neural coordination.

This study examines how postpartum sleep restriction in rat mothers affects their and their offspring's immunity, finding sex-specific impacts on offspring antibody levels and lymphocyte counts.