Topic · Cardiology and Cardiovascular Medicine · Medicine

Renin-Angiotensin System Studies

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

Neuroscience·bioRxivPreprint·Oct 24, 2026
Want to read
Aldosterone drives HSD2 neuron activity and molecular remodeling of synaptic function to promote sodium appetite
Miriam C. McDonough, Ahmet Kuralay, Trevor C. Butler…+4 more authors·Jon M. Resch
The paper shows aldosterone enhances synaptic transmission in HSD2 neurons through SV2C, driving sodium appetite.
DOI 10.64898/2026.10.21.759848
mouse·bulk RNA-seq
·𝕏 Post·Bluesky
Pharmacology & Toxicology·bioRxivPreprint·Oct 13, 2026
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AT1R-Selective Negative Allosteric Modulator Targeting the Epitope for Pathogenic Autoantibody Activation
Khuraijam Dhanachandra Singh, Triveni R. Pardhi, Terri J. Harford…+5 more authors·Sadashiva S. Karnik
This paper develops TP1, an AT1R-selective negative allosteric modulator that blocks autoantibody binding and preserves orthosteric functions, showing therapeutic potential for autoimmune conditions.
DOI 10.64898/2026.10.12.758523
human·experimental assay
·𝕏 Post·Bluesky
Physiology·bioRxivPreprint·Oct 11, 2026
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BCKDK Inhibitors Directly Antagonize Angiotensin II Type 1 Receptor and Induce Vasodilation Independently of BCAA Catabolism or BCKDK
Ryo Kawakami, Yann Deleye, Esra Akkaya…+13 more authors·Robert W. McGarrah
This study shows BCKDK inhibitors cause vasodilation by directly blocking the AT1R, independent of BCAA catabolism or BCKDK.
DOI 10.64898/2026.10.06.757051
mouse·experimental assay
·𝕏 Post·Bluesky