Frailty in Older Adults

This study links clonal hematopoiesis to accelerated frailty and functional decline across multiple organ systems in humans.

This study uses UK Biobank data to develop an 18-year mortality risk estimator for domain-specific intrinsic capacity, identifying immune system activation across domains.

This study identifies molecular signatures for frailty using transcriptomic data from two datasets, highlighting vitamin D metabolism and inflammatory pathways as key features.

This study shows that monocyte behaviors can predict aging and frailty in humans using single-cell analysis and a deep learning model.

This paper uses multi-polygenic scores to predict frailty and its trajectories, identifying chronic pain, rheumatoid arthritis, and educational attainment as key pathways.

This study validates a polygenic risk score for frailty using two independent cohorts, showing it predicts frailty at early ages with moderate variance explained.