Metabolism and Genetic Disorders

Naloxone, a NOX2 inhibitor, largely restored mitochondrial networks and curbed a pro-fibrotic signature in LCHADD/VLCADD patient fibroblasts, and rescued impaired vessel formation in 3D bioprinted vascularized constructs.

TAFAZZIN-knockout C2C12 myoblasts show elevated proline catabolism into the TCA cycle alongside reduced collagen content, proline hydroxylation, crosslinking enzyme LOX, and proline incorporation into ECM proteins.