Insect Resistance and Genetics

This study shows that Aedes aegypti mosquitoes developing in brackish water have thicker cuticles and higher insecticide resistance compared to those developing in fresh water.

This study identifies APN3 as a functional receptor for Cry4Ba toxin in Aedes aegypti, showing its role in toxin binding and larvicidal activity through genetic knockout experiments.

dsRNAEngineer is a web tool for designing dsRNA molecules targeting pests while avoiding non-pest organisms, using transcriptome data to improve specificity and efficiency.

This study shows that PBO inhibits cytochrome P450, reducing deltamethrin efficacy by altering Nav channel interactions through an octopamine-dependent pathway.

The paper identifies polygenic resistance mechanisms to Bt crops in Helicoverpa zea, highlighting gene copy number variation and trypsin gene upregulation as key factors.

This study examines genetic diversity in the IIS6 domain of the VGSC gene in Aedes aegypti across India, identifying mutation frequencies and their correlation with insecticide resistance and population structure.

This study identifies a genomic duplication of multiple P450 genes in Aedes aegypti that enhances deltamethrin resistance and reveals its evolutionary origin and fitness costs.

This study identifies CYP325G4 and CYP6AA9 as key P450 enzymes involved in deltamethrin resistance in Culex pipiens legs through transcriptome and proteome analysis.

This study shows that temperature affects the efficacy of insecticidal dsRNA in Colorado potato beetle larvae, while plant cultivar does not.

This study shows that knocking out SfVipR1 in Spodoptera frugiperda confers high-level resistance to Vip3Aa toxin but not Cry1Fa.

This study identifies gene mutations associated with pyrethroid resistance in bed bugs by comparing genomes of resistant and susceptible strains.

This paper demonstrates that simultaneous silencing of intestinal nucleases and a vital gene via dsRNA feeding significantly improves RNAi efficiency and mortality in Mediterranean fruit fly adults.

This study investigates insecticide resistance in Myzus persicae by comparing sensitivity of specific genotypes to various insecticides and screening for resistance mutations.

The paper identifies a Vip3Aa resistance gene in fall armyworm using CRISPR-mediated chromosome deletion and multi-omics analysis, revealing CHS2 as a candidate gene responsible for resistance.

This study identifies genetic loci associated with flubendiamide resistance in Helicoverpa armigera using GWAS and QTL mapping, revealing an oligogenic architecture and potential molecular markers for resistance monitoring.

The paper identifies partial selective sweeps at insecticide resistance genes in Aedes mosquitoes, showing independent evolution and spread of resistance alleles across different regions.

The paper compares transcriptomic responses to pyrethroid treatment in two closely related bed bug strains with differing resistance, finding few constitutive gene differences but many induced genes related to detoxification.

This study identifies amino acids that differentiate deltamethrin-resistant from susceptible Aedes albopictus mosquitoes using GC-MS and logistic regression.

This study identifies highly effective target genes for RNA interference-based control of the cabbage stem flea beetle, showing 100% mortality and reduced leaf damage with dsRNA.

The paper identifies introgression of OWBW-specific CYP337B3 alleles into CEW in Colorado, linking it to pyrethroid resistance and agricultural impact.

This study identifies molecular mechanisms of pyrethroid and spinosad resistance in Drosophila suzukii through transcriptome analysis and validates findings using Drosophila melanogaster mutants.

The paper designs modified Bt Cry1BM and Cry1CM genes for Brassicas to reduce licensing costs and IP issues, showing high insecticidal efficacy in transgenic Arabidopsis.

The paper demonstrates that CUAD-based oligonucleotide insecticides can effectively control aphids at a low cost, with minimal environmental impact.

This study shows that silencing Ruvbl1 in corn planthoppers reduces egg production and hatching, suggesting it as a potential target for RNAi-based insect control.

This paper reviews the molecular mechanisms and species-specific efficacy of CUADb-based oligonucleotide insecticides and RNAi-based RNA biocontrols for plant protection against insect pests.

The paper identifies potential RNAi targets for cotton mealybug management using proteome data and evaluates dsRNA delivery for pest control.

The paper analyzes genetic diversity in four insecticide resistance genes of Aedes aegypti across global populations to identify mutations and copy number variations associated with insecticide resistance.