Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

This study uses RNA-seq to analyze gene expression in male and female avian primordial germ cells, revealing sex-biased gene expression and suggesting a combination of cell-autonomous and somatic regulation in sex determination.

The paper identifies sex-linked markers in the Australian frog Platyplectrum ornatum, revealing two distinct population clusters with different sex-determining systems.

This study identifies GATA transcription factors as essential for initiating Xist upregulation and X-chromosome inactivation in mouse embryos through direct activation of a distal enhancer.

The paper analyzes transcriptome changes in silkworm larvae overexpressing a piRNA-resistant Masculinizer gene, finding global repression of Z-linked genes in females but minimal effect on males.

This study identifies TRIM28's role in preventing female-to-male sex reversal in the adult mouse ovary by maintaining the ovarian pathway through SUMOylation.

The paper examines how DCC binding affects gene expression changes on the X chromosome in Drosophila under various treatments, finding that DCC-bound genes are less likely to be up- or down-regulated.

The paper determines the structural basis of the interaction between CLAMP and MSL2 proteins, showing how this interaction enables specific recruitment of the dosage compensation complex to the male X chromosome in Drosophila.

This study identifies widespread recombination suppression on the X chromosome of the dwarf hamster, showing it is independent of structural changes and associated with heterochromatin formation.

This study examines meiotic pairing and double strand break formation in threespine stickleback sex chromosomes, finding that they pair non-homologously and repair breaks similarly to autosomes.

The paper investigates X-chromosome upregulation (XCU) in mouse embryos and finds it is not global, differs between ancestral and acquired X-linked genes, and may not drive the evolution of X-chromosome inactivation (XCI).

The paper identifies and characterizes a previously uncharacterized supporting-like cell lineage in developing mouse gonads, showing its origin, specification, and sex-specific differentiation.

This study investigates X-chromosome inactivation and reactivation dynamics in female mouse PGCLCs, showing that a precise temporal sequence is critical for meiotic potential.

The paper examines X chromosome inactivation in the human placenta and finds it is patchy, differing from the mosaic pattern observed in adult tissues.

The paper shows that deletion of X-linked palindromic gene families 4930567H17Rik and Mageb5 does not affect male fertility, spermatogenesis, or gene regulation, but may influence sperm head morphology.

The paper investigates how chromosomal content and gonadal sex influence gene expression and DNA modification patterns in mouse hippocampi, revealing sex chromosome-specific regulatory effects.

The paper investigates XIST repression on the future active X in human and bovine preimplantation embryos using single-cell RNA sequencing and qRT-PCR, identifying potential repressors and timing of XIST expression.

The paper maps recombination rates and genetic variation along the Z chromosome of great reed warblers, revealing extreme recombination variation and its impact on diversity and repeats.

The paper compares analytical methods for studying young sex chromosomes in guppies, finding that reference genome choice significantly affects results.

The paper shows SPEN and Polycomb work together in parallel for Xist-mediated gene silencing, and SmcHD1 recruitment is needed for silencing X-linked genes during differentiation.

FindZX detects and visualizes sex chromosomes using whole-genome sequencing data across diverse species and taxonomic groups.

The paper investigates early dosage compensation in Drosophila melanogaster and finds that it occurs through a post-transcriptional mechanism rather than transcriptional regulation.

The paper investigates how high incubation temperatures reprogram sex in dragon lizards, finding that genetic factors outweigh temperature effects in determining gonadal development.

The paper identifies a truncated duplication of the amhr2 gene on the Y chromosome in Pangasiid catfishes as a conserved master sex-determining gene.

The paper identifies sex chromosomes in the spider Argiope bruennichi using cytogenetic and genomic methods and develops RT-qPCR sex markers.

This paper describes a method to isolate C. elegans males by degrading DPY-27, enabling molecular and biochemical analyses of male-specific processes.

The paper investigates the relative contributions of sex hormones, sex chromosomes, and gonads to sex differences in gene regulation in liver and adipose tissues using the FCG mouse model.

This study uses allele-resolved single-cell multi-omics to reveal the dynamics and transcriptional kinetics of X-chromosome upregulation in mouse development.

The paper identifies small silencing RNAs targeting PxyMasc, a male-determining gene in diamondback moth, expressed from W-linked retrocopies on the female-specific chromosome.

This study shows that Lhx2 in germ cells suppresses endothelial cell migration in developing ovaries, leading to increased angiogenesis.

The paper identifies Nup107 as a mediator of female sexual differentiation through its regulation of Dsx and BMP signaling in Drosophila.