Thermoregulation and physiological responses

The paper develops two models to estimate internal temperatures in a near-term fetus, showing they align with measured temperatures and demonstrate how changes in umbilical cord heat exchange affect fetal temperatures.

This study identifies miRNA-regulated networks in human heatstroke that link stress-survival signalling to impaired protein quality control and metabolic flexibility.

The paper identifies a conserved molecular response to heat stress in the central nervous system and links cerebellar vulnerability to intrinsic metabolic and electrophysiological properties.

The paper identifies CACNA2D4 variants associated with exertional heat stroke susceptibility and shows their impact on calcium signaling in skeletal muscle.

This paper uses magnetic resonance spectroscopy to non-invasively map thigh temperatures during cold water immersion and exercise, showing significant temperature changes across different thigh regions.

This study shows that rapid humidity increases in heat tolerance tests underestimate human heat tolerance due to non-equilibrium physiological responses, suggesting slower protocols or prolonged exposures are more accurate.

Controlled 8-hour indoor trials with 36 hydrated young adults establish empirical heat-survival maps across 32-35°C wet-bulb temperatures, showing uncompensable heat at 34-35°C and longer female endurance.

This study shows that gradual heat exposure in mice triggers sex-specific changes in immune responses and metabolism, affecting cytokines, microbiota, and metabolites.

This study shows that CTIP and biophysical models overpredict heat risk, as healthy adults maintained heat balance across extreme heat conditions.

This study examines the effects of fluid replacement on inflammation, thermoregulation, and organ stress during extreme heat exposure, finding that it reduces core temperature but worsens inflammation and electrolyte imbalances.

The paper identifies hypothalamic preoptic neurons that develop warm-sensitive activity during heat acclimation, enabling heat tolerance through cell-autonomous mechanisms.

This study investigates how rats respond to water spraying by analyzing fur changes, behavior, and drying processes using thermal imaging.

This study examines the effect of coat color on thermal status in Labrador Retrievers and finds no significant difference between black and yellow dogs.