3D Printing in Biomedical Research

This study shows dicarbonyl stress increases cancer cell intravasation by degrading ECM and promoting endothelial dysfunction in a microfluidic model.

This paper develops a 3D bioprinted liver fibrosis model using GelMA and dECM, validated with methotrexate to induce fibrosis and assess functional and molecular changes.

The paper presents a microfluidic organ-on-chip method to study immune cell responses to drug-treated tumor cells in 3D.

This paper introduces a thermoplastic chip for single-cell immune assays that enables screening and high-resolution imaging of immune cell responses in 2D and 3D cultures.

This paper introduces a lung tumor-on-a-chip model that simulates hypoxia and evaluates its impact on radiotherapy response and FDG-PET imaging.

This study develops a light-based bioprinting method using decellularized extracellular matrix to create anisotropic cartilage scaffolds that promote tissue maturation and mimic native structure.

The paper develops a toxicokinetic model to measure and predict chemical-PDMS interactions in organ-on-chip devices, showing accurate dose prediction under continuous-flow conditions.

This study investigates how microfluidic flow parameters affect solute transport in 3D cell cultures, showing that chamber size, inlet velocity, and confinement influence solute distribution and penetration depth.

This study shows that pancreatic ductal adenocarcinoma cells in collagen droplets form branched organoids with complex morphology, suggesting accelerated maturation compared to traditional bulk culture.

This study develops tunable porcine skin-derived hydrogels for 3D bioprinting, optimizing their mechanical properties and printability to support cellular growth and structure formation.

This paper presents a low-cost, open-access 3D-printed Gut-on-Chip method for gut research, demonstrating its functionality with Caco-2 cells.

This study evaluates how scaffold composition affects PDAC organoid phenotype, metabolism, and drug resistance, finding that collagen-Matrigel mixtures best mimic invasive tumors.

This paper introduces a high-throughput microfluidic platform for organoid culture and multi-omics profiling, demonstrating its utility in clinical and drug discovery settings.

This study enhances the maturity and functionality of liver organoids by combining 3D bioprinting with vascular progenitor cells and a pillar plate culture system.

This study develops a 4D bioprinted self-folding scaffold that enhances cartilage formation in engineered trachea by enabling eCPCs to respond to scaffold curvature.

This paper develops a 3D in vitro kidney model with immune cells to study inflammation and injury, showing monocyte migration and response to inflammatory stimuli.

This paper presents 3D printed microstructured alginate scaffolds with tetrapod-shaped ZnO templates that enhance neuron adhesion and maturation.

This paper develops a hybrid bioink combining self-assembled peptides and alginate to create a stiff, printable, and self-healing material with improved biocompatibility for tissue engineering and biosensing.

This study develops a microfluidic chip model of endochondral ossification using human stem cell-derived organoids, showing vascular-like network formation and interactions.

This paper develops a 3D-printed organ-on-chip platform with a tubing-free pump to model lymph node communication during vaccination.

This paper develops a high-throughput microfluidic system to generate reproducible 3D leukemia microenvironments for drug testing, showing that stroma-leukemia interactions protect cells from drug-induced cytotoxicity.

This paper develops a method to create serially perfusable multiscale capillary beds in vitro for studying vascular biology and integration into organoid and organ-on-a-chip models.

This study develops a method to fabricate and assemble organoid units for creating larger, transplantable organ-like structures.

This paper introduces a 4D bioprinting platform that enables programmable shape-morphing of tissues through viscoelastic hydrogels, enhancing structural and functional properties of iPSC-derived heart tissues.

This paper introduces a soft-lithography-based acoustic bioassembly technique to create complex multicellular structures with functional liver tissue mimic capabilities.

This paper introduces HITS-Bio, a high-throughput spheroid bioprinting system that enables scalable tissue fabrication with high cell viability and speed.

This study develops clickable PEGNB microbeads that enable suspension bioprinting and microvascular self-assembly for engineering hierarchical vasculature.

This study introduces a 3D tumor model called ToP for generating predictive cancer models and screening therapeutics for glioblastoma and pancreatic adenocarcinoma.

This paper introduces a human kidney epithelial microphysiological platform (Epi-MAP) to model collecting duct physiology from stem cells, enabling advanced functional analysis and drug testing.

This paper introduces a soft robotics-driven method to achieve programmable 3D cell alignment in bioprinted tissue through dynamic mechanical stimulation.