Björn Önfelt

The paper identifies immune cell subsets with distinct functional behaviors based on plasma membrane order using biophysical profiling and transcriptome analysis.

Tumors shape the hierarchy of CD155-CD112 receptors, reducing TIGIT blockade efficacy, while CD226 drives NK infiltration and shows binding plasticity.

This study evaluates a microwell system for isolating individual NK cells, demonstrating its viability and potential for functional screening but noting its limited throughput.

This paper introduces a thermoplastic chip for single-cell immune assays that enables screening and high-resolution imaging of immune cell responses in 2D and 3D cultures.

This study shows that deleting adhesion ligands CD54 and CD58 on allogeneic immune cells reduces NK cell rejection without impairing their anti-tumor activity.