Meningioma and schwannoma management

The paper identifies functional glutamatergic synapses between meningioma cells and neurons, showing they promote tumor invasion and proliferation.

The paper characterizes the IOMM-Lee cell line as a model for NF2-wildtype malignant meningioma, identifying its genomic features, radiosensitivity, and drug response to multiple anti-cancer agents.

This study identifies developmental meningeal mosaicism as the origin of human meningiomas, showing that driver mutations are present in phenotypically normal meninges and shared across tumors.

The paper identifies PTEN loss as a driver of aggressive NF2 mutant meningiomas and validates a cross-species model for preclinical testing.

The paper generates a single-cell and spatial transcriptomic atlas of human fetal meninges and finds that meningiomas likely originate from dura lineage cells.

This study uses single-cell and spatial transcriptomics to identify mutation-associated gene expression programs in meningiomas, linking genetic alterations to tumor and immune cell states.

This study integrates phospho-proteogenomic and single-cell transcriptomic data to subtype meningiomas and identify subtype-specific immune infiltration patterns.

The paper identifies a distinct genetic subgroup of low-grade meningiomas through gene expression profiling, suggesting potential for improved diagnosis and treatment.