Neuroinflammation and Neurodegeneration Mechanisms

AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans

This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.

Masitinib mediates TGF-Beta1 and Nitric Oxide Secretion and Ameliorates MPTP/Microglia-Induced Degeneration of Differentiated SH-SY5Y Cells

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

This study identifies phosphatidylserine (PS) as a neuronal signal that marks synapses for elimination by microglia during development.

Asperosaponin VI inhibits LPS-induced inflammatory response by activating PPAR-gamma pathway in primary microglia

This study shows that asperosaponin VI reduces LPS-induced inflammation in microglia by activating the PPAR-gamma pathway.

A developmental analysis of juxtavascular microglia dynamics and interactions with the vasculature

This paper analyzes juxtavascular microglia dynamics in mice and humans, showing their developmental migration along vessels and stabilization as astrocyte endfeet ensheath the vasculature.

Activation of the pro-resolving receptors Fpr2/3 attenuate lipopolysaccharide-induced inflammatory microglial activation

This study shows that activating Fpr2/3 receptors reduces LPS-induced inflammation in microglia by inhibiting NFκB and promoting resolution.

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

This study shows that 25-HC enhances IL-1β production in microglia, particularly in apoE4-expressing cells, suggesting a role in AD neuroinflammation.

Methotrexate carried in lipid core nanoparticles reduces microglial activation and is neuroprotective after ischemic cortical stroke

This study shows that LDE-MTX reduces microglial activation and increases neuronal preservation after experimental cortical stroke in rats.

Reversal of β-amyloid induced microglial toxicity in vitro by activation of Fpr2/3

This study shows that activating Fpr2 with QC1 reverses β-amyloid-induced microglial toxicity in vitro by reducing ROS production and metabolic shifts.

Microglial activation results in neuron-type-specific increase in mPFC GABAergic transmission and abnormal behavior in mice

This study shows that microglial activation in the mPFC increases GABAergic transmission and causes abnormal behavior in mice, which can be mitigated by blocking microglial activation or administering BDNF.

Single Cell-type Integrative Network Modeling IdentifiedNovel Microglial-specific Targets for the Phagosome inAlzheimer's disease

The paper develops a computational systems biology approach to identify novel microglial-specific targets for the phagosome in Alzheimer's disease using integrated transcriptome and genotype data.

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

This study identifies proteomic changes in microglia during Alzheimer's disease progression in mouse models, showing fibrillar Aβ drives microglial dysfunction.

Alzheimer’s patient brain myeloid cells exhibit enhanced aging and unique transcriptional activation

The paper identifies a novel transcriptional signature in human Alzheimer's myeloid cells that differs from mouse models and shows aging-related and AD-specific gene expression changes.

Microglia dysfunction caused by the loss of Rhoa disrupts neuronal physiology and leads to neurodegeneration

This study shows that loss of Rhoa in microglia causes neurodegeneration through Src-mediated Tnf production and excitotoxic glutamate secretion.

Decoding the transcriptional response to ischemic stroke in young and aged mouse brain

The paper analyzes RNA-Seq data from young and aged mice after ischemic stroke to identify age-related transcriptional changes and inflammatory responses.

Control of microglial dynamics by Arp2/3 and the autism and schizophrenia-associated protein Cyfip1

This study identifies the role of Arp2/3 and Cyfip1 in regulating microglial dynamics and suggests their involvement in neuropsychiatric diseases.

Sex hormones underlying 17a-Estradiol effects on neuroinflammation

This study shows 17a-Estradiol reduces neuroinflammation in male mice but not females, with effects mediated by gonadal hormones and region-specific brain changes.

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding

This study identifies a specific GPR56 splicing isoform that mediates microglial synaptic pruning through phosphatidylserine binding, linking it to neurodevelopmental processes.

Study of pre-synaptic internalisation in human schizophrenia brains

The paper investigates microglial synaptic internalisation in schizophrenia post-mortem brains and finds no differences in microglial activation or pre-synaptic protein levels between schizophrenia and control cases.

Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice

This study shows that chronic activation of hM3Dq in microglia reduces neuroinflammation and sickness behavior in mice by modulating cytokine responses.

Probing the functions of microglial cyclin-dependent kinase 5 under physiological and pathological conditions

This study investigates the role of Cdk5 in microglia under physiological and pathological conditions, finding transcriptional changes but minimal effects on morphology and behavior.

Primate-specific response of astrocytes to stroke limits peripheral macrophage infiltration

The paper identifies primate-specific astrocyte responses to stroke, showing NogoA limits macrophage infiltration and suggests therapeutic targeting.

Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer's disease

Microglial phagocytosis dysfunction is related to local neuronal activity in a genetic model of epilepsy

This study shows that microglial phagocytosis dysfunction in a genetic epilepsy model is linked to local neuronal activity, suggesting a role for neuronal activity in phagocytosis impairment.

Single-cell resolution analysis of the crosstalk between chemogenically activated astrocytes and microglia

The paper uses DREADD-activated astrocytes and single-cell RNA sequencing to show transcriptomic changes in astrocytes and microglia, highlighting gene pathways involved in neurogenesis and immune responses.

Phf15, a novel transcriptional repressor regulating inflammation in mouse microglia

This study shows Phf15 represses pro-inflammatory genes and antiviral responses in microglia, regulating inflammation during aging and LPS stimulation.

Chronic Intermittent Ethanol and Lipopolysaccharide Exposure Differentially Alter Iba-1-Derived Microglia Morphology in the Prelimbic Cortex and Nucleus Accumbens Core

This study examines how chronic ethanol and LPS exposure alter microglial morphology in specific brain regions, revealing distinct morphometric changes.

The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes beneficial microglial functions

This study identifies a protective Plcγ2-P522R variant in Alzheimer's disease by showing it enhances microglial functions like phagocytosis and survival.

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors

This study shows HERV-K(HML-2) RNA activates TLR8 and Tlr7, causing neurodegeneration in mice and correlating with AD in humans.

Distinct cellular mediators drive the Janus Faces of Toll-like Receptor 4 regulation of network excitability which impacts working memory performance after brain Injury

This paper identifies distinct cellular mechanisms by which TLR4 regulates network excitability and working memory after brain injury, showing TNF's role in mediating these effects.