Xiao Chen

AAB-seq: An antigen-specific and affinity-readable high-throughput BCR sequencing method

AAB-seq identifies antigen-binding antibodies with affinity information from single-cell BCR sequencing in immunized mice.

DHHC7 palmitoylates KRAS4A and promotes mutant KRAS-driven pancreatic cancers

This study identifies DHHC7 as a palmitoyl transferase that modifies KRAS4A, enhancing its membrane localization and activation, and shows that targeting DHHC7 inhibits pancreatic tumor growth.

Myeloid cells contribute to bystander CD8 T cell accumulation in metabolic-associated steatohepatitis and are sufficient for fibrosis

This study shows myeloid cells, not conventional T cells, drive fibrosis in MASH by retaining CD8 T cells in the fibrotic niche.

Reliability and validity of multi-band multi-echo fMRI

This study evaluates the reliability and validity of multi-band multi-echo fMRI for mapping individual differences in spontaneous brain activity, showing improved reliability and detectable differences in resting states.

Plasma Induced Afterglow Luminescence

This paper explores cold atmospheric plasma as a stimulus to generate long-lasting afterglow from organic matter for biomedical applications.

Cold Atmospheric Plasma for Alzheimer's disease

This study shows that cold atmospheric plasma (CAP) modulates Alzheimer's disease progression in mice by enhancing neuroimmune signaling without causing harm in healthy mice.

GOBoost: Leveraging Long-Tail Gene Ontology Terms for Accurate Protein Function Prediction

GOBoost improves protein function prediction by addressing long-tail distribution of Gene Ontology Terms using an ensemble strategy and specialized loss functions.

Comprehensive analysis of GBA using a novel algorithm for Illumina whole-genome sequence data or targeted Nanopore sequencing

The paper presents two methods to accurately detect GBA variants and reciprocal recombinants, showing higher GBA variant frequency in Lewy body dementia compared to Parkinson's disease.

Probing the functions of microglial cyclin-dependent kinase 5 under physiological and pathological conditions

This study investigates the role of Cdk5 in microglia under physiological and pathological conditions, finding transcriptional changes but minimal effects on morphology and behavior.

HiAlc Klebsiella pneumonia, one of potential chief culprits of non-alcoholic fatty liver disease: through generation of endogenous ethanol

This study identifies HiAlc Klebsiella pneumoniae as a contributor to non-alcoholic fatty liver disease by inducing endogenous ethanol production in mice and humans.