Topic · Infectious Diseases · Medicine

Clostridium difficile and Clostridium perfringens research

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

3 papers

A host-directed virulence factor of Clostridium perfringens is modulated by gut commensal strains

Julia Schumacher, Paolo Stincone, Johanna Rapp, Timo-Niklas Lucas, Carlos Llaca-Bautista, Francesca Barletta, Mirita Franz‐Wachtel, Boris Maček, Daniel H. Huson, Lisa Maier, Hannes Link, Daniel Petras, Bastian Molitor

The paper investigates how gut commensal strains modulate the growth and virulence of Clostridium perfringens through substrate competition and protein level changes.

Gut Microbes · Oct 29, 2026Peer-reviewedMicrobiology

Gnotobiotic OMM12 mice support sustained Clostridioides difficile colonization without antibiotic pretreatment

Devon E. Conti, Eva Chatonnat, Quentin Lamy-Besnier, Thirishika Manivannan, Aline Crouzols, Léo C. Caulat, Céline Mulet, Marion Berard, Laurent Debarbieux, Bruno Dupuy, Julian R. Garneau

This study shows that gnotobiotic OMM12 mice can sustain Clostridioides difficile colonization for 20 days without antibiotic pretreatment, allowing research on host-microbiota-pathogen interactions.

bioRxiv · Oct 28, 2026 · PreprintMicrobiology

Adaptation of the Geometric Viability assay as a high throughput assay to measure Clostridioides difficile spore germination

Kyle Vogtman, Amy E. Rohlfing

The paper adapts the Geometric Viability assay to measure C. difficile spore germination, finding it highly consistent with conventional methods and capable of detecting germination sensitivity differences.

bioRxiv · Oct 21, 2026 · PreprintMicrobiology