Bruno Dupuy

This study shows that gnotobiotic OMM12 mice can sustain Clostridioides difficile colonization for 20 days without antibiotic pretreatment, allowing research on host-microbiota-pathogen interactions.

This study shows that TcdE holin is essential for toxin secretion and virulence in C. difficile, as tcdE mutants exhibit reduced toxin release and less virulence in mice.

This study shows that CDT toxin from Clostridioides difficile induces biofilm-like microcolonies, increasing colonization and persistence in intestinal models and infected mice.

This study identifies monoclonal antibodies targeting C. difficile's S-layer protein, revealing both protective and detrimental effects on bacterial physiology.

The paper develops a monoclonal antibody collection targeting C. difficile strains to improve research on clinically relevant ribotypes.

The paper develops regulatory, metabolic, and integrated models for C. difficile to understand its colonization mechanisms and interactions with the gut microbiota.