Laurent Debarbieux

This study shows that gnotobiotic OMM12 mice can sustain Clostridioides difficile colonization for 20 days without antibiotic pretreatment, allowing research on host-microbiota-pathogen interactions.

This study identifies DNA-damaging bacteriocins from E. coli that induce prophages and promote lysogeny in the gut microbiota.

The paper investigates the 3D genome structuration and dynamics of bacteriophage PAK_P3 during infection of Pseudomonas aeruginosa, revealing specific interactions between phage and host genomes.

The paper describes an amyloid-based signal transduction mechanism in Escherichia coli's antiphage defense system, showing functional interchangeability between Bab and fungal HET-S amyloids.

This study shows that macrophages reduce bacteriophage density in the lungs, limiting the effectiveness of phage therapy in treating Pseudomonas aeruginosa pneumonia.

This study uses computational models to show that phage cocktails targeting different bacterial receptors improve treatment outcomes in immunocompromised hosts and reduce resistance evolution.

This study investigates how phage-phage competition and biofilm formation affect the efficacy of a two-phage combination against Pseudomonas aeruginosa in vitro.

This paper predicts phage-bacteria interactions at the strain level using genomic data from Escherichia isolates and shows tailored phage cocktails are more effective.

This study uses a spatially structured metapopulation model and in vivo experiments to evaluate how lung anatomy and immune responses affect the efficacy of phage therapy for Pseudomonas aeruginosa infections.