Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
63 papers
Lu Qiu, Meng Wang, Shaofan Hu…·Yiguo Zhang
This study shows that Nrf1 knockout leads to Nrf2 hyperactivation, promoting hepatoma, and reveals a feedback loop between Nrf1 and Nrf2 in tumor suppression.
Arun Jyothidasan, Gobinath Shanmugam, John H. Zhang…·Rajasekaran Namakkal Soorappan
This study investigates the basal role of excess Nrf2 in regulating mRNA and miRNA interactions in the mouse myocardium using transgenic mice and high-throughput sequencing.
Lu Qiu, Meng Wang, Yuping Zhu…·Yiguo Zhang
The paper identifies a naturally-occurring Keap1 mutant, Keap1{Delta}C, that acts as a dominant-negative competitor, reducing Keap1's ability to inhibit Nrf2 and thereby increasing Nrf2-target gene expression.