Venomous Animal Envenomation and Studies

This study uses Thermal Proteome Profiling and PISA to assess marimastat's specificity against snake venom toxins, identifying its targets and interactions with specific proteoforms.

This study identifies intraspecific venom variation in Naja mossambica across three African populations, revealing high neurotoxic protein content and antivenom reactivity differences.

This paper develops a fluorescence-based high-content assay to identify venom-induced cellular activities like membrane lysis, pore formation, and ion channel modulation across different cell types.

This paper shows that melatonin receptor agonists promote functional recovery from krait venom-induced neuroparalysis in mice, suggesting their potential use in human snakebite treatment.

This study develops humanized antibody scFvs against Elapidae and Viperidae snake venoms, identifies PLA2 as a key toxin, and shows their in vivo neutralization efficacy.

VIDAL is a machine-learning tool that automatically analyzes dermonecrosis in mouse models to assess antivenom efficacy, offering an accurate and reproducible alternative to manual methods.

This study introduces VenomSeq, a platform that uses transcriptomics and differential gene expression to link venoms to drugs and diseases, generating new therapeutic hypotheses.

This paper validates a colorimetric LAMP assay for detecting Loxosceles envenomation, showing high sensitivity and specificity compared to PCR.

The paper investigates the role of an aromatic cage in the lipid specificity of Loxosceles α clade phospholipase D enzymes using molecular dynamics simulations and experimental validation.

The paper characterizes the skin transcriptomic profiles of Oophaga poison frogs to understand the genetic basis of their aposematic traits and chemical defenses.

The paper compares toxin-associated gene homologs in Daboia russelii using whole-genome sequencing data from skin exuviate, identifying unique sequence motifs and structural residues across venom domains.