Author

Cara Francesca Smith

Liverpool School of Tropical MedicineORCID 0000-0002-6868-7713Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Anthony J. SaviolaiD· 2 shared Cassandra M. ModahliD· 2 shared David Ceja GalindoiD· 2 shared Keira Y. LarsoniD· 2 shared Kirk Charles HanseniD· 2 shared Lilyrose BahrabadiiD· 2 shared Maxwell C. McCabeiD· 2 shared Nicklaus BrandehoffiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPharmacology & Toxicology

Anthony J. SaviolaORCID

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3 papers

Recent·Most cited

Evolutionary BiologyProceedings of the National Academy of SciencesPeer-reviewedSep 4, 2026

The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes

Jory van Thiel, Noah L. Dowell, Cara Francesca Smith…·Sean B. Carroll

This study traces the genomic origins of four procoagulant venom toxins in Australian snakes and identifies a fifth toxin, showing two distinct evolutionary paths for their development.

DOI 10.1073/pnas.2621054123

mousewhole-genome sequencing

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Pharmacology & ToxicologyJournal of Thrombosis and HaemostasisPeer-reviewedMar 22, 2025

Discerning Specific Thrombolytic Activities and Blood Clot Degradomes of Diverse Snake Venoms with Untargeted Peptidomics

Cara Francesca Smith, Mamadou Aliou Baldé, Stephanie French…·Anthony J. Saviola

This study uses untargeted peptidomics and thrombolysis assays to analyze the clot-degrading effects of six snake venoms, revealing specific targets and mechanisms of thrombolysis.

3 citations

proteomicsexperimental assay

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BiochemistryMolecular & Cellular ProteomicsPeer-reviewedApr 26, 2024

ASSESSING TARGET SPECIFICITY OF THE SMALL MOLECULE INHIBITOR MARIMASTAT TO SNAKE VENOM TOXINS: A NOVEL APPLICATION OF THERMAL PROTEOME PROFILING

Cara Francesca Smith, Cassandra M. Modahl, David Ceja Galindo…·Anthony J. Saviola

This study uses Thermal Proteome Profiling and PISA to assess marimastat's specificity against snake venom toxins, identifying its targets and interactions with specific proteoforms.

10 citations

mouseproteomics

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