Effects of Radiation Exposure

This study uses RNA-seq to analyze gene expression changes in human blood after X-ray exposure, identifying novel radiosensitive genes and pathways.

This study develops a human ex vivo skin model that recapitulates radiation-induced DNA damage and fibrotic responses, identifying p53-driven pathways and potential therapeutic targets.

This study uses a blood-brain barrier microphysiological system to show radiation induces sterile inflammation via mitochondrial DNA release and cGAS-STING signaling, with potential therapeutic targets identified.

This study examines how pre- and post-fertilization X-ray exposure affects Xenopus laevis development, finding varying lethality and anomaly rates based on dose and timing.

MIIST305 improves survival and gut health in irradiated mice by restoring microbiota balance and reducing inflammation.

This study uses MRI to differentiate between unirradiated mice and those exposed to conventional or FLASH radiotherapy, finding distinct brain changes after conventional but not FLASH treatment.

This study shows that telomerase mRNA reduces radiation-induced DNA damage in human skin cells by enhancing DNA repair and reducing mitochondrial ROS without extending telomere length.

The paper estimates mutation frequencies in human cells under different proton doses using a combined mathematical model for space exploration risk assessment.

This paper establishes a novel murine tail irradiation model to study radiation-induced skin injury, finding dose-dependent fibrosis and dynamic melanin changes.

This study establishes a hairless mouse model of radiation dermatitis that mimics human disease, showing severe skin injury and specific histopathological markers for preclinical research.

This study examines the long-term behavioral effects of galactic cosmic radiation on female mice and evaluates the protective effects of an antioxidant compound.

The paper evaluates the differential biological effects of low-dose ionizing radiation on radiosensitive and radioresistant cell lines, finding distinct responses in DNA damage, apoptosis, and gene expression.

This study evaluates the reproducibility and temporal evolution of FLASH and CONV irradiation effects on mice, showing FLASH sparing at late but not early time points.

This study shows nicotine accelerates but makes DNA repair more error-prone in human lung cells exposed to alpha radiation, potentially increasing genomic instability.

This paper develops a faster radiation biodosimetry method using G0-PCC with RABiT-II, enabling same-day testing for radiation emergencies.

FLASH proton radiotherapy improves normal tissue toxicity without compromising anti-tumor efficacy by coordinating IFN-I signaling across stromal, immune, and revSC networks.

This study evaluates how varying radiation beam parameters affect gastrointestinal toxicity and tumor response in mice, finding that high dose per pulse and ultra-high dose rate independently reduce toxicity while maintaining tumor control.

Maternal administration of mitochondrial-targeted JP4-039 mitigates fetal brain injury and preserves mitochondrial function after mid-gestation radiation exposure.

This study demonstrates that the cis-MoO2(BHAN)2 complex effectively protects DNA from radiation-induced damage, with 90% protection at 2 mM concentration against 20 Gy radiation.

This study investigates radiation-induced changes in energy metabolism in salivary glands, finding altered glycolytic and oxidative phosphorylation rates and mitochondrial dysfunction over time.

This study finds that paternal exposure to ionizing radiation increases clustered de novo mutations in offspring, suggesting cDNMs as a transgenerational biomarker.

This study investigates the metabolic changes in mouse hippocampus after low-dose radiation exposure using metabolomics and multi-omics integration, identifying altered pathways linked to neurodegenerative diseases.

This study shows FLASH-RT and CONV-RT produce similar levels and proportions of chromosome translocations and junction structures under various oxygen conditions.

This study shows that RPRM deletion reduces radiation-induced brain injury in mice by targeting multiple mechanisms including DNA damage, neurogenesis, inflammation, and microglial activation.

This study examines mutational profiles in human cells exposed to proton and alpha radiation, finding subtle changes in mutation spectra and distributions but not overall increased mutation rates.

This study shows that pelvic irradiation in rats causes gut dysbiosis, leading to behavioral changes, intestinal damage, and reduced brain neuronal maturation and plasticity.

This study evaluates how age and sex affect gene expression-based radiation biodosimetry in mice, finding that while accuracy varies, age and sex must be considered for effective dose prediction.

This paper describes ADCI Online, a secure cloud-based platform for radiation dose estimation using dicentric chromosome assays, achieving results comparable to local systems in under 2 days.

The paper shows that low-dose rate γ-irradiation reduces chromosome breaks and telomere fusions in Drosophila by modulating Loquacious expression.

This study investigates the role of the Wnt canonical pathway in radiotoxicity via oxidative stress in mice, finding that radiation inhibits the pathway and impairs DNA repair and sperm function.