Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology

Natural product bioactivities and synthesis

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

3 papers

Cancer BiologybioRxivPreprintSep 8, 2025

Evaluating the therapeutic efficacy of the US FDA-designated Orphan drug, uttroside B in impeding hepatocarcinogenesis via induction of immunogenic apoptosis, using a murine model of Aflatoxin B1-induced liver carcinogenesis

Mundanattu Swetha, Chenicheri Kizhakkeveettil Keerthana, Tennyson Prakash Rayginia…·Ruby John Anto

This study evaluates uttroside B's efficacy in preventing AFB1-induced hepatocarcinogenesis in mice by inducing immunogenic apoptosis and blocking immune checkpoints.

DOI 10.1101/2025.09.08.674785

mousebulk RNA-seq

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintAug 17, 2025

Identification of molecular pathways involved in the anti-liver cancer activity of madecassic acid

Geraud N. Sansom, Emily P. Friar, David Shorthouse…·Christopher J. Serpell

This study identifies molecular pathways of madecassic acid's anti-liver cancer activity using chemical proteomics and RNAseq, showing its interactions with proteins related to metabolism and nucleic acid processing.

DOI 10.1101/2025.08.17.670739

humanbulk RNA-seq

𝕏 PostBluesky

Pharmacology & ToxicologyPharmaceuticsPeer-reviewedAug 13, 2025

Promising protocol for in vivo experiments with betulin

Pavel Šiman, Aleš Bezrouk, Alena Tichá…·Mohamed Niang

This paper describes a method for administering betulin in vivo and analyzing its levels in organs, showing improved solubility and a synergistic effect with Namitecan on tumors.

3 citations

mouserat

𝕏 PostBluesky