Invertebrate Immune Response Mechanisms

This study shows that microbiota influences sex-specific infection outcomes in mealworm beetles, with females being more susceptible and microbiota depletion reducing this dimorphism.

The paper compares phagocytic processing of native and foreign Vibrio isolates in sponges, finding differential cellular and proteomic responses.

This study identifies wsv100 as a WSSV protein that inhibits the NF-kappaB pathway in shrimp, suppressing immune responses and enhancing viral replication.

This study investigates the maintenance of diptericin A alleles in Drosophila by analyzing immune responses, sex-specific effects, and microbiome composition across different genotypes.

The paper shows that adding immune-primed migrants to small inbred populations improves survival against pathogens, while non-primed migrants only enhance reproduction.

This study identifies Toll-9 as a key receptor for antiviral immunity against Drosophila C virus, showing it binds dsRNA, activates RNAi, and induces apoptosis.

This study identifies 27 CLIPs in Anopheles gambiae that form two subnetworks regulating antimicrobial activity and infection resistance through baseline co-expression rather than infection-induced upregulation.

This study shows that innate immune pathway activation can promote tumor growth when combined with oncogenic Ras in Drosophila.

This study uses proteomics to analyze Drosophila hemolymph after bacterial infection, identifying new proteins and changes in mitochondrial respiration.

The paper shows that the SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response in Drosophila larvae during parasitoid wasp infection.

The paper identifies chromatin regulators in C. elegans that repress immune responses to intracellular pathogens, linking developmental regulation to immune control.

The study shows that chronic juvenile malnutrition in Drosophila leads to improved early-life pathogen tolerance but increased late-life infection susceptibility.

This study demonstrates that cryopreserved Octopus vulgaris hemocytes maintain viability above 80% and functional phagocytic ability for at least two months, enabling long-term immune function studies.

The paper identifies spia-1 as a gene involved in immune activation in C. elegans by sensing cuticle damage through its secreted protein with a novel cysteine-cradle domain.

The paper identifies novel Ig-domain features in Porifera, suggesting potential primitive adaptive immunity mechanisms.

The paper investigates how dietary resources affect developmental shifts and infection tolerance in flour beetles coinfected with gregarine and bacterial parasites, finding that resources modulate developmental timing but not resistance to bacterial infection.

This study shows that the timing of starvation affects Drosophila melanogaster's susceptibility to E. faecalis infection, with post-infection starvation improving survival regardless of prior treatment.

This study investigates how D. melanogaster evolves resistance and disease tolerance to oral bacterial infection through experimental evolution.

This study shows that the fungus Beauveria bassiana causes cell loss in the Drosophila brain through Toll-1/Wek/Sarm signaling, which drives immune evasion.

The paper presents a chromosome-level genome of Mnemiopsis leidyi, revealing unique immune gene domains and their expression in response to pathogen exposure.

This study examines immune gene expression in African snails exposed to Schistosoma mansoni and evaluates diet effects on gene expression.

This study identifies Attacin-D as a nonsecretory antimicrobial peptide that mediates immune-induced organ damage in Drosophila renal tubules upon Imd pathway activation.

This study uses genome editing in Drosophila to trace the evolution of horizontally transferred immune toxins, showing fusionB enhances survival and suppresses parasitoid wasp development.

The paper identifies a bacterial sensing mechanism in neurons that activates intestinal mitochondrial surveillance to protect against infections.

This study shows that mitochondrial DNA variation influences innate immune responses and infection outcomes in Drosophila by affecting gene expression and immune cell function.

This study investigates the evolutionary distribution and functional diversification of g-type lysozymes across metazoans, revealing lateral gene transfer and specialized roles in immunity and digestion.

The paper shows that Pkc53E-mediated phosphorylation of Su(H) inhibits Notch signaling, enabling Drosophila to mount an effective immune response against parasitic wasps.

This paper identifies two C-type lectin receptor pairs in C. elegans that mediate recognition of specific oomycete pathogens and show they are co-regulated and function redundantly in host defense.

This study shows that inhibiting translation initiation in C. elegans increases survival during P. aeruginosa infection, while inhibiting elongation decreases survival, due to distinct immune responses.