Bruno Lemaître

This study identifies NimB2 as an opsonin in Drosophila that enhances recognition of Staphylococcus aureus by macrophages through binding to lipoteichoic acid and the receptor Eater.

This study identifies Skanda, a serine protease homolog, as a modulator of the Toll-phenoloxidase immune cascade in Drosophila, showing it dampens Hayan activation and contributes to immune response.

This paper shows that antimicrobial peptides damage neurons by binding to exposed phosphatidylserine, and that Turandot proteins protect neurons by reducing this interaction.

The paper tests if high-risk social insect workers invest more in immune defenses but finds no evidence for risk-dependent immune investment in clonal ants.

This study investigates Drosophila immune responses to diverse fungal pathogens, identifying the Toll pathway and melanization as key defenses, while highlighting fungal adaptations to evade these mechanisms.

This study identifies NimB1 as a secreted protein that inhibits early apoptotic cell phagocytosis in Drosophila by binding phosphatidylserine on apoptotic cells, opposing the function of NimB4.

The paper assesses the replicability of claims in Drosophila immunity research by analyzing 400 publications and identifying contradictory evidence.

This study retrospectively analyzed 400 Drosophila immunity papers to assess replicability, finding 61% of claims were verified, 7% challenged, and 24% unchallenged, with irreplicability linked to author experience and field trends.

This study shows that gut bacteria provide methionine, which modulates RNA m6A methylation of the insulin receptor, thereby promoting host reproduction in Bactrocera dorsalis.

This study identifies Paillotin as a novel Drosophila immune peptide regulated by the Imd pathway, showing increased susceptibility to specific infections in mutants.

This study uses proteomics to analyze Drosophila hemolymph after bacterial infection, identifying new proteins and changes in mitochondrial respiration.

This study systematically evaluates the roles of four immune modules in Drosophila by deleting them individually and collectively, revealing their independent and synergistic contributions to defense against various pathogens.

This study identifies vitamin B6 synthesis by intestinal bacteria as critical for promoting Bactrocera dorsalis larval growth under poor diet conditions.

The paper shows Duox in Drosophila Malpighian tubules produces ROS that trigger Upd3 release, which then stimulates gut epithelial renewal via a countercurrent flow system.

The paper identifies a renal-gut countercurrent flow in fruit flies that enhances gut immune response by promoting ROS accumulation and peristalsis through bacterial tyramine recognition.

This study shows that Svb, an OvoL factor in Drosophila, integrates signaling inputs to regulate intestinal stem cell self-renewal and differentiation through post-translational processing and context-dependent transcriptional activity.