Invertebrate Immune Response Mechanisms

This study identifies JAK-STAT signaling and Upd-like as critical for midgut regeneration and infection tolerance in Aedes aegypti.

This study investigates disease tolerance in Drosophila by exposing it to heat-killed Pseudomonas entomophila, finding that mortality and fecundity reduction depend on exposure duration, sex, and bacterial virulence, with microbiota exacerbating effects.

This study investigates whether Imd-dependent AMPs mediate indirect interactions between gut microbiota and pathogens in a tripartite context, finding that Imd-independent AMPs and microbiota-mediated immune priming influence infection outcomes.

This study shows that Drosophila melanogaster selected for increased early-life reproduction under protein limitation show reduced immune resistance and survival after infection, with these effects being sex-specific and mitigated by mating.

The paper shows infected mosquitoes adjust their diet to reduce parasite load and extend lifespan, suggesting self-medication despite benefits in uninfected individuals.

This study shows that REL2/NF-κB signaling regulates midgut bacterial homeostasis in Anopheles gambiae, with loss of REL2 causing dysbiosis and reduced Plasmodium falciparum prevalence.

This study shows that diacylglycerol (DAG) metabolism in Drosophila midgut enterocytes regulates host-pathogen responses by controlling defecation and bacterial clearance.

This study investigates Drosophila immune responses to diverse fungal pathogens, identifying the Toll pathway and melanization as key defenses, while highlighting fungal adaptations to evade these mechanisms.

The paper examines immune gene expression variability in ant colonies infected by a non-lethal fungus, finding differing responses among workers, queens, and larvae.

This study shows that Serratia marcescens outer membrane vesicles trigger apoptosis in Drosophila neurons, leading to rapid paralysis through reactive oxygen species and the metalloprotease PrtA.

This study shows that methylparaben reduces the virulence and transmissibility of Pseudomonas entomophila in Drosophila, highlighting the impact of food preservatives on pathogen behavior.

This study shows that Tep3 limits macrophage attachment to damaged and transformed epithelia by inhibiting MMP1 proteolytic activity, reducing BM DAMP production and promoting tumor progression.

This paper investigates immune priming in the gut of Tribolium castaneum using RNA sequencing and transmission electron microscopy, showing that priming leads to gut damage, stress response, and gene upregulation that enhances protection against subsequent infection.

This study challenges the assumed antiviral role of Vago genes in Aedes aegypti by showing that VLG-1 has a modest proviral effect during DENV and ZIKV infections.

This study identifies an ancient evolutionary origin of IL-1 cytokines in invertebrates, showing they share key features with mammalian IL-1 proteins and suggest a foundational role in animal immunity.

This study identifies a conserved TNF signaling pathway in Anopheles gambiae that regulates immune cell function and limits Plasmodium parasite survival.

This study investigates the role of Ptr23c in Drosophila hemocyte differentiation and distribution, finding that it regulates timing rather than quantity.

This study shows that microbiota influences sex-specific infection outcomes in mealworm beetles, with females being more susceptible and microbiota depletion reducing this dimorphism.

This study shows that pathogen-induced neuronal signaling disrupts lysosomal function and collagen homeostasis in C. elegans, identifying NSIF-1 and ELT-3 as key regulators.

The paper compares phagocytic processing of native and foreign Vibrio isolates in sponges, finding differential cellular and proteomic responses.

This study identifies wsv100 as a WSSV protein that inhibits the NF-kappaB pathway in shrimp, suppressing immune responses and enhancing viral replication.

This study identifies LmGypsy, a retrotransposon in locusts, as a mediator of antiviral immunity that synergizes with RNAi and cGAS-like receptors to defend against viral infection.

This study identifies carotenoid-rich coelomocytes in sea cucumbers, challenging the assumption that hemocytes contain haemoglobin and proposing a new classification as carotenocytes.

The paper shows that adding immune-primed migrants to small inbred populations improves survival against pathogens, while non-primed migrants only enhance reproduction.

This study shows that Drosophila midgut progenitors detect pathogenic bacteria via PGRP-LC/LE and activate MKK3-p38 signaling to drive ISC proliferation and midgut regeneration.

This study identifies immune cell types in the basal chordate Ciona robusta using single-cell RNA sequencing and finds divergence from vertebrate immune cells.

This study identifies Toll-9 as a key receptor for antiviral immunity against Drosophila C virus, showing it binds dsRNA, activates RNAi, and induces apoptosis.

This study identifies Paillotin as a novel Drosophila immune peptide regulated by the Imd pathway, showing increased susceptibility to specific infections in mutants.

The paper investigates how venom vesicles from Ganaspis hookeri parasitoid wasps facilitate the entry of venom proteins, including SERCA, into host immune cells to suppress immune responses.

This study identifies 27 CLIPs in Anopheles gambiae that form two subnetworks regulating antimicrobial activity and infection resistance through baseline co-expression rather than infection-induced upregulation.