Invertebrate Immune Response Mechanisms

The paper sequences the genome of Drosophila innubila and finds that antiviral RNAi genes evolve slowly, contrasting with Drosophila melanogaster, suggesting different evolutionary pressures for DNA and RNA virus resistance.

This study identifies two C. elegans-specific genes, pals-22 and pals-25, which function as antagonistic regulators controlling the switch between growth and pathogen resistance.

This study shows that the Toll pathway inhibits tissue growth and enhances cell fitness in an infection-dependent manner by regulating apoptosis and proliferation.

The paper shows that genetic variation in energy metabolism in Drosophila leads to immunity-fecundity tradeoffs, particularly in females under resource limitation.

This study shows that ins-11, an insulin peptide gene in C. elegans, is upregulated by different pathogens in specific tissues and influences immune responses and longevity.