Invertebrate Immune Response Mechanisms

The paper uses computational models to show that host-pathogen feedbacks can lead to divergent infection outcomes, even with similar initial conditions.

The paper shows that immune priming with inactivated WNV reduces transmissible WNV infection in mosquitoes by reversing immune suppression through enhanced gene expression.

The paper performs high-resolution RNA-seq time course analysis of Drosophila immune response to Imd stimulation, identifying gene expression dynamics and trade-offs with metabolic processes.

The paper identifies functional differences in JAK-STAT signaling between anterior and posterior progenitors in the Drosophila lymph gland, showing how compartmentalization affects immune response.

This study identifies two C. albicans proteins essential for epithelial infection of planarians and describes a multi-system host response involving stem cells and distinct tissues.

This study identifies five compounds that enhance Caenorhabditis elegans resistance to multiple pathogens by activating host defense pathways.

This study identifies the vascular niche as a second regulator of Drosophila hematopoiesis, showing that FGF signaling from vascular cells maintains hematopoietic progenitors.

This study shows that odor exposure in Drosophila larvae increases systemic GABA and blood-progenitor Sima levels, enhancing lamellocyte induction and immune response efficiency.

The paper identifies additional mutations in the NimrodC1 phagocytosis receptor in widely used egr3 mutant Drosophila strains, which may affect phagocytic function.

This study shows Dscam1 supports blood cell survival in Drosophila by acting in both sensory neurons and hemocytes, with effects mediated through the adapter protein Dock.

The paper profiles the transcriptome of Lymnaea stagnalis to identify immune-related genes and their expression under various immune and environmental conditions.

The paper uses single-cell RNA sequencing to analyze myeloid blood cell lineages in Drosophila, identifying novel cell types and lineage dynamics during immune responses.

The paper shows that Gypsy retrotransposon activation during Drosophila metamorphosis primes innate immunity, enhancing viral clearance in adult flies.

The paper uses scRNA-seq to compare how two viruses affect enteroendocrine cells in Drosophila, showing subtype-specific replication strategies and gene expression changes.

This study shows that insulin-like signaling coordinates Drosophila larval hemocyte number with body size, with reduced growth rate and impaired signaling leading to fewer hemocytes.

The paper examines how captivity affects amebocyte cell quality in Tachypleus gigas and finds captivity reduces cell viability, while anticoagulant formulations significantly impact cell density, viability, and morphology.

The paper identifies a mechanism by which oxygen-sensing neurons in Drosophila larvae promote blood cell transdifferentiation through the activity of the guanylyl cyclase Gyc88E.

The paper identifies functionally distinct plasmatocyte subpopulations in Drosophila regulated by efferocytosis and shows how their behavior and abundance can be modulated.

The paper identifies context-specific roles of Notch signaling in different progenitor populations during Drosophila larval hematopoiesis.

The paper uses bulk and single-cell RNA sequencing to study Drosophila hemocyte heterogeneity across developmental stages and immune challenges, identifying novel cell types and functional states.

The paper compares transcriptional responses to bacterial pathogens in Drosophila and Caenorhabditis, finding conserved and divergent gene expression patterns.

The paper develops a hemocyte-specific promoter tool in Anopheles gambiae to study immune functions and pathogen interactions in malaria mosquitoes.

This study identifies APL1 as a single ancestral gene in most Anopheles species and shows its expansion to three paralogs in the Gambiae complex, with distinct functional roles in immunity and malaria transmission.

The paper shows that parental exposure to P. vranovensis increases offspring survival through upregulation of CYSL-1, CYSL-2, and RHY-1.

The paper examines the transcriptional responses of Spodoptera frugiperda tissues to Steinernema carpocapsae infestation, identifying gene expression changes and potential immune effectors acquired via horizontal gene transfer.

The paper shows that antimicrobial peptides (AMPs) suppress tumor growth in Drosophila mxc mutants by inducing apoptosis in tumor cells.

The paper sequences the genome of Drosophila innubila and finds that antiviral RNAi genes evolve slowly, contrasting with Drosophila melanogaster, suggesting different evolutionary pressures for DNA and RNA virus resistance.

This study identifies two C. elegans-specific genes, pals-22 and pals-25, which function as antagonistic regulators controlling the switch between growth and pathogen resistance.

This study shows that the Toll pathway inhibits tissue growth and enhances cell fitness in an infection-dependent manner by regulating apoptosis and proliferation.

The paper shows that genetic variation in energy metabolism in Drosophila leads to immunity-fecundity tradeoffs, particularly in females under resource limitation.