Cerebrospinal fluid and hydrocephalus

This study shows that GIT 27 reduces astrocyte attachment and cytokine levels when used as a pre-treatment for shunt insertion.

The paper models CSF circulation to show that convection in the subarachnoid space rapidly clears tracers from intracranial compartments, reducing clearance time from years to days compared to diffusion.

This study identifies membrane transporters involved in cerebrospinal fluid (CSF) secretion and shows their role in modulating intracranial pressure.

This study shows pneumococcal meningitis impairs the glymphatic system, leading to bacterial accumulation in CSF and neuronal damage due to AQP4 misplacement.

This paper introduces a non-contrast spin-labeling MRI technique to quantify CSF outflow in humans and finds that CSF flow metrics decline with age.

The paper shows sleep cycle-dependent changes in perivascular spaces enhance cerebrospinal fluid flow and solute transport in sleeping mice.

This study examines the immediate effects of yogic breathing on pulsatile cerebrospinal fluid (CSF) dynamics using MRI, finding increased cranial CSF velocities during certain breathing patterns.

The paper establishes the 3D anatomy of meningeal lymphatic vasculature and CSF drainage in mice and humans using imaging techniques, showing conserved lymphatic structures.

The paper profiles the transcriptome of rat choroid plexus to identify transport mechanisms and regulatory pathways involved in cerebrospinal fluid secretion.

This study characterizes non-human primate dura in health and neurodegeneration, revealing a complex lymphatic system and disease-specific biomarker associations.

This study uses a poroelastic model to show that arteriolar dilation drives convective fluid flow in the brain, enhancing waste clearance during sleep and sensory activity.

The paper models glymphatic flow as a network of hydraulic resistances under different parametric scenarios to identify key parameters influencing CSF dynamics.

This study identifies a mutation in Trim71 that causes congenital hydrocephalus by impairing stem cell differentiation through repression of Lsd1 mRNA translation.

This study shows altered brain fluid circulation dynamics in a mature-onset AD mouse model, linked to amyloid plaque burden and neuroinflammation.

This study uses dynamic MRI with contrast agent to assess CSF clearance pathways in humans, finding age-related decline and a link between peri-olfactory pathway function and sleep/cognitive health.

This study identifies lysophosphatidic acid (LPA) as a biomarker for posthemorrhagic hydrocephalus and shows it drives CSF accumulation through TRPV4-induced hyperactivation of NKCC1.

This study uses fMRI to investigate the coupling between cerebrovascular oscillations and CSF flow during wakefulness, finding bidirectional CSF movement and low-frequency facilitation by hemodynamics.

This study shows that bilateral common carotid stenosis impairs glymphatic function and vascular pulsation in mice, contributing to cognitive decline in vascular cognitive impairment.

This study shows acetazolamide reduces intracranial pressure directly by acting on the choroid plexus in rats, without relying on systemic effects.

The paper investigates how autonomic regulation of cerebral vascular tone generates CSF pulsations during sleep and may aid in brain waste clearance.

This study investigates the effect of nasal inhalation of prostaglandin F2alpha analogs on cerebrospinal fluid (CSF) outflow via nasal lymphatics in mice, finding increased tracer recovery with latanoprost.

This study maps CSF pathways in the CNS using gold nanoparticle enhanced X-ray microtomography and identifies region-specific circulation patterns affecting stem cell and neuronal populations.

This study uses MRI to track CSF flow in juvenile mouse brains, finding increased permeability in specific regions until postnatal week 1.

The paper compares brain lymphatic endothelial cells (BLECs) to scavenging endothelial cells (SECs) in the zebrafish and identifies Mrc1a as a key receptor for cargo uptake in BLECs.

This study identifies OTX2's roles in adult choroid plexus function through knockdown models and proteomic analysis, revealing its impact on secretion, immune responses, and RNA processing.

This study finds that reduced coupling between global brain activity and cerebrospinal fluid flow is associated with cognitive impairment in Parkinson's patients.

The paper demonstrates that bulk CSF flow in periarterial spaces is not an artifact of injection, using a dual-syringe system that prevents volume changes and pressure increases.

The paper investigates glymphatic function in a large mammal with a highly gyrified brain, showing CSF penetration and enhanced solute transport compared to mice.

The paper identifies potassium-driven cerebrospinal fluid (CSF) clearance through the choroid plexus during a critical neurodevelopmental phase in mice, showing its role in preventing hydrocephalus.

This study shows that photostimulation of meningeal lymphatic vessels in mice with intraventricular hemorrhage reduces mortality and improves recovery by enhancing red blood cell clearance.