Cerebrospinal fluid and hydrocephalus

The paper analyzes cerebral perivascular spaces (PVS) in healthy individuals to establish normal ranges and identifies factors like BMI, time of day, and genetics that influence PVS volume and distribution.

The paper characterizes astrocyte endfoot dimensions along the vascular tree in mice and shows that varying endfoot sizes maintain perivascular-interstitial fluid flux despite pressure changes.

This study shows that focused ultrasound with microbubbles improves beta-amyloid drainage in Alzheimer's model mice by enhancing brain-to-cerebrospinal fluid clearance.

This study shows that functional hyperemia drives fluid exchange in the paravascular space by interacting with brain tissue deformability.

This study shows that increasing convective forces after intrathecal injection improves rostral distribution of therapeutic ASOs in the CNS of cynomolgus monkeys.

The paper reconciles fluid dynamics theory, simulation, and in vivo measurements of CSF flow in mouse brains by applying realistic boundary conditions.

This study uses fluid dynamic simulations to show that arterial pulsations cause oscillatory CSF motion, not directional pumping, and that directional flow results from pressure differences.

The paper shows that coupling between global brain activity and CSF inflow correlates with Alzheimer's disease pathology using ADNI data.

This study shows that glutamate and GABA modulate glymphatic clearance of amyloid β through distinct mechanisms involving pulsation and AQP4, with potential therapeutic implications for Alzheimer's disease.

The paper identifies a specialized neuro-texture in the caudal thoracic spinal cord of monkeys, consisting of NADPH-d positive neurons and plexus structures that may function as CSF sensors.

The paper quantifies uncertainty in tracer distribution in the brain by simulating diffusion and convection models and comparing results to experimental MRI data.

The paper shows that the observed shapes of perivascular spaces (PVSs) in the brain have lower hydraulic resistance than concentric, circular annuli, allowing faster cerebrospinal fluid flow.

This study investigates the anatomical and physiological role of cerebrospinal fluid transport through the murine cribriform plate and finds that olfactory sensory nerves are critical for CSF outflow.

This paper presents numerical simulations of cerebrospinal fluid dynamics models to confirm and extend theoretical results from a mathematical perspective.

This study uses dynamic 11C-PiB PET to show reduced cerebrospinal fluid clearance in Alzheimer’s disease and multiple sclerosis compared to healthy controls.

The paper compares two mathematical models of cerebrospinal fluid dynamics using numerical simulations and validates them against real data from literature.

This study confirms that AQP4 is essential for glymphatic fluid and solute transport in the rodent brain, as Aqp4 disruption reduces CSF influx and amyloid-beta efflux.

This study identifies MPDZ as a gene linked to hydrocephalus in mice, showing that its loss-of-function causes choroid plexus hyperpermeability and increased cerebrospinal fluid protein concentration.

The paper investigates the applicability of Davson’s equation in idiopathic normal pressure hydrocephalus patients, finding a weak but significant correlation between intracranial pressure and outflow resistance.

This study examines the relationship between cerebral autoregulation, CSF outflow resistance, and surgical outcomes in normal pressure hydrocephalus patients.