Adipose Tissue and Metabolism

This paper shows that codon-optimized FAM132b gene therapy via AAV9 reduces obesity and improves glucose homeostasis in mice by modulating adrenergic response and insulin action.

The paper uses a CRISPR-based screen in 3T3-L1 cells to identify regulators of adipogenesis, finding that protein translation and stability mechanisms are critical for adipocyte expansion and lipogenesis.

The paper presents a framework for identifying cellular heterogeneity and markers in adipose tissue using transcriptomics, validated with an independent dataset and analyzing 779 samples across multiple conditions.

This study shows that allicin activates brown adipose tissue, improving metabolic health in diet-induced obese mice.

The paper identifies gene networks in brown adipose tissue of mice that are influenced by genetic background and diet, linking them to obesity and diabetes traits.

This study identifies differentially expressed miRNAs in rabbit perirenal adipose tissue across growth stages and links them to adipose-related pathways.

This study identifies α-ketoglutaric acid (AKG) as a metabolite that promotes muscle hypertrophy and fat loss via OXGR1-dependent adrenal activation in response to resistance exercise.

The paper shows that adipose tissue becomes neuropathic in metabolic disorders and demonstrates ways to stimulate neural plasticity to restore metabolic health.

This study shows that chicken RB1 inhibits preadipocyte proliferation by affecting the G1/S cell cycle transition.

The paper identifies proteomic and metabolic changes in brown fat tissue in response to cold exposure, highlighting increased acetylation and lipid synthesis.

This study shows that loss of TLE3 enhances mitochondrial function in beige adipocytes, improves glucose metabolism, and prevents weight gain.

This study shows that HDAC11 suppresses thermogenic programs in adipose tissue via BRD2, leading to improved metabolic outcomes in HDAC11-deficient mice.

CITGeneDB curates human and mouse genes that enhance or suppress cold-induced thermogenesis through perturbation experiments in mice, providing a searchable database for research on obesity and diabetes.

This study shows that estrogen receptor inhibition improves cold-induced adipocyte beiging and glucose sensitivity in mouse models.

This study shows that Egr1 deficiency promotes browning of inguinal white adipose tissue in mice by enhancing Ucp1 expression and reducing extracellular matrix genes.

This study shows cinnamon extract increases UCP3 gene expression in obese rats' skeletal muscle, with low doses being more effective than higher doses.