Adipose Tissue and Metabolism

Tamoxifen Targets Wisp2 to Impair Subcutaneous Adipocyte Progenitor Self-Renewal and Adipogenic Differentiation

This study shows tamoxifen reduces subcutaneous adipocyte progenitor self-renewal and adipogenesis by suppressing Wisp2, linking endocrine therapy to metabolic risks like T2D.

Human brown adipose tissue demonstrates substantial 18F-fluorocholine uptake at room temperature for phosphatidylcholine synthesis

This study shows that 18F-fluorocholine PET can detect human brown adipose tissue at room temperature by measuring phosphatidylcholine synthesis, without requiring cold exposure.

A Cell-Autonomous Cold Sensor Promotes Lipolysis Through Phase Separation

The paper identifies a cell-intrinsic cold-sensing mechanism that enhances lipolysis through phase separation of perilipin 1 in adipose tissue.

Genomic Profiling of Estrogen-Related Receptor Identifies Adult Adipocyte-Specific Targets in Drosophila

The paper identifies ERR-specific genomic targets in adult Drosophila adipocytes using NanoDam, revealing its role in regulating metabolic pathways.

Endothelial CXCL12 is dispensable for adipose tissue function

This study investigates the role of CXCL12 in adipose tissue endothelial cells and finds it dispensable for adipose tissue function under normal and cold conditions, as well as during obesity.

An amyloid-β/APP regulatory layer in human brown adipocyte recruitment identifies repurposable drugs for thermogenic fat expansion

Androgen Receptor mediates beige adipocyte homeostasis and plasticity

This study shows that androgen receptor signaling regulates beige adipocyte remodeling, mitochondrial function, and metabolic adaptation in male mice.

Aged white adipose tissue is rejuvenated in a young host through thermogenic remodeling of mature adipocytes

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

Stress-induced Metabolic Remodeling of Adipose and Brain Tissue Revealed by Positron Emission Tomography

This study uses PET and multi-OMICS to show stress activates brown adipose tissue and alters brain metabolism in mice, identifying metabolic hubs and signatures relevant to mental health and disease models.

ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance

This study shows that the ENPP1 K173Q variant reduces cGAMP hydrolysis, leading to increased extracellular cGAMP and insulin resistance in brown adipose tissue.

Exosome Trafficking Is a Key Regulator of Adipocyte Thermogenesis

This study identifies exosome trafficking as a key regulator of beige adipocyte thermogenesis, showing that exosome release enhances thermogenic output and energy expenditure.

Probing the transcriptome response to shivering in skeletal muscle using a multilayered bioinformatics approach

The paper analyzes the transcriptomic response of human skeletal muscle to repeated shivering using bioinformatics approaches, identifying a sex-specific transcriptional signature that diminishes with cold adaptation.

Mitochondrial genome instability disrupts brown adipose tissue through pseudohypoxia-iron-NAD⁺ axis

This study identifies a pseudohypoxia-iron-NAD+ axis as a key driver of brown adipose tissue dysfunction in mitochondrial disease using a mouse model.

Brown adipocyte fatty acid synthase (FASN) deficiency protects mice from alcohol-induced elevations in plasma triglyceride and hepatic steatosis

This study shows that brown adipocyte FASN deficiency reduces alcohol-induced plasma triglycerides and hepatic steatosis by enhancing thermogenesis and VLDL uptake.

Differential Nucleotide Inhibition Profile of Mouse and Human UCP1 Expressed in Liver Mitochondria Is Associated with an F88S Mutation

This study compares the bioenergetic properties of human and mouse UCP1 expressed in liver mitochondria, revealing differences in nucleotide regulation linked to an F88S mutation.

Orai1-mediated Ca2+ Entry Regulates Lipolysis and Mitochondrial Activation in Brown Adipose Thermogenesis

This study identifies Orai1 as a regulator of Ca2+ entry in brown adipocytes, linking it to lipolysis, mitochondrial activation, and thermogenesis during cold exposure.

Only a fraction of UCP1 is required to sustain adaptive nonshivering thermogenesis in the cold

This study shows that only a fraction of UCP1 is needed for maximal thermogenic capacity in cold-acclimated mice, as reducing UCP1 by 80% did not impair thermogenesis, but complete deficiency did.

Single-Nucleus Analysis of Human White Adipose Tissue Reveals Adipocyte Subsets with Distinct Metabolic Profiles

The paper identifies distinct adipocyte subsets in human white adipose tissue with different metabolic profiles and links TSHZ3 to their regulation and metabolic disease associations.

Adaptation of white adipocytes to cooler temperatures: impacts on energy metabolism and protein acetylation

This study shows that cooling reduces protein acetylation in adipocytes, affecting mitochondrial function and metabolism without changing enzyme expression or acetyl-CoA availability.

Molecular heterogeneity and differential metabolic signatures in thymic adipocytes

The paper characterizes thymic adipocyte heterogeneity and metabolic signatures in mice, identifying two distinct subpopulations with distinct transcriptional and chromatin features.

Lineage Tracing Reveals a Shared Cellular Origin for Supraclavicular Brown and Inguinal Beige Adipocytes

This study identifies a shared cellular origin for supraclavicular brown adipocytes and beige adipocytes in inguinal white adipose tissue through lineage tracing.

Beige/brown fat-mediated cardiac protection from high-fat diet is dependent on adipocyte beta3-adrenergic receptor

This study shows that adipocyte beta3-adrenergic receptor activation protects against high-fat diet-induced cardiac damage by promoting beige fat formation and adipose-cardiac communication.

Adipocyte Expression of O-Glycoprotein Procollagen C-Endopeptidase Enhancer Protein 2 (PCPE2): Mechanisms Linking Fibrosis and Beiging of White Adipose Tissue

This study shows that Pcpe2 in adipose tissue contributes to inflammation and fibrosis in obesity and that its absence reduces these effects and enhances adipocyte differentiation.

Identification and functional assessment of GPCRs across human adipogenesis

This paper identifies and functionally assesses GPCRs during human adipogenesis, revealing novel expression patterns and therapeutic targets.

Complementary remodeling strategies distinguish human subcutaneous and omental adipose tissue

The paper compares subcutaneous and omental adipose tissue in humans, finding distinct transcriptional identities and remodeling strategies linked to metabolic risk.

Adipose GPD2 Couples Glycolytic Signals to Epigenetic Control of Metabolic Homeostasis

This study identifies GPD2 as a key regulator linking glycolytic signals to epigenetic control of thermogenesis and metabolic homeostasis in adipose tissue.

Primary Hyperparathyroidism Reveals Limited Adipose Remodeling in Human

This paper investigates the effects of chronic PTH excess in PHPT on adipose tissue in humans and finds no significant thermogenic or energy-dissipating changes, but identifies a selective secretory phenotype.

Brown fat protects against hepatic oxidative stress by remodeling the circulating metabolome

This study identifies BAT-derived metabolites that protect the liver from oxidative stress by remodeling the circulating metabolome.

Endotome as a Source of Human Peri-Aortic Brown Adipocytes

The paper identifies the endotome as a MYF5-independent source of human peri-aortic brown adipocytes and describes their developmental pathway and functional properties.

A Cold-Responsive Mitochondrial Transporter Stimulates Brown Adipose Tissue Thermogenesis

This study identifies Slc25a34 as a cold-responsive mitochondrial transporter that facilitates AMP transport to activate thermogenesis in brown adipocytes.