Lymphatic System and Diseases

This study shows that Tbx1 and Vegfr3 interact genetically to regulate cardiac lymphangiogenesis, with dosage balance required for proper vessel development.

This study identifies S1PR1 as a regulator of lymphatic vessel quiescence by inhibiting LSS-dependent VEGF-C signaling in lymphatic endothelial cells.

This paper uses single-cell transcriptomics to map the transcriptional organization of lymphatic endothelial cells in mouse and human lymph nodes, identifying distinct subsets and their functional roles.

This study shows that overactive p53 in lymphatic endothelial cells causes lymphatic defects in mice and human tissues, and normalizing p53 restores lymphatic function.

This study identifies BACH family members as regulators of VEGFC expression, impacting angiogenesis and lymphangiogenesis in zebrafish and mouse models.

This study shows that Cdc42 is essential for lymphatic vessel branching, maturation, and valve formation during embryonic development.

This study shows that RASA1 is required for the development of lymphovenous and venous valves by regulating collagen IV export from endothelial cells in mice.

This study characterizes the distribution and function of ocular lymphatics in mice and rats, showing nasal-side dominance and suggesting its clinical relevance for glaucoma surgery site selection.

This study shows that S1P-S1PR1 signaling promotes VEGF-A-dependent lymphatic endothelial cell proliferation and limits migratory responses during lymphatic vessel development.

This study identifies miR-204 as a key regulator of lymphangiogenesis, showing its role in lymphatic vessel formation and its interaction with NFATC1.

This study shows that cerebrovascular injuries in zebrafish trigger lymphatic invasion into brain parenchyma, which helps resolve edema and guides vascular regeneration.

This study identifies GATA2's role in maintaining lymphatic endothelial cell junctions and valve morphogenesis through regulation of miR-126.