Lymphatic System and Diseases

This study examines human lymphatic vessel development in embryos and fetuses, finding Prox1-expressing LECs originate from cardinal veins and showing organ-specific developmental patterns.

The paper identifies a specialized mesenteric lymphatic capillary network that bypasses mesenteric lymph nodes to directly transport peritoneal antigens into mediastinal lymph nodes.

This study shows that Rictor is essential for AKT signaling in lymphatic valve formation, as its deletion reduces valve numbers and impairs valve maturation.

This study shows that VEGF-C overexpression enhances brain fluid drainage, provides neuroprotection, and improves stroke outcomes in mice.

The paper uses 3D imaging to study the vascular development of the mouse epididymis, revealing the organization of blood and lymphatic networks during development.

This study creates a mouse model overexpressing VEGF-C in kidney progenitor cells, revealing increased lymphangiogenesis and a cystic kidney phenotype resembling human renal lymphangiectasia.

This study shows eNOS regulates lymphatic valve specification by controlling β-catenin signaling during embryogenesis, independent of nitric oxide production.

This study identifies a genetic interaction between svep1 and tie1 in zebrafish lymphatic development, independent of Vegfc, and links it to human glaucoma.

This study uses single-cell transcriptomics to investigate Prox1's role in lymphatic endothelial cell fate specification and differentiation in zebrafish, identifying new transcriptional targets and regulatory mechanisms.

This study identifies VEGFC and VEGFD as essential mediators of coronary lymphangiogenesis, with a sex-specific role for VEGFD in females.

This study identifies SOX7 as a transcription factor in blood vascular endothelial cells that represses Vegfc expression, influencing lymphatic vessel patterning in mice.

This study identifies PDE2A as a regulator of lymphatic endothelial development through cGMP-mediated control of Notch signaling, showing its role in junction maturation and cell cycle arrest.

This study conducts a GWAS on a UK lipoedema cohort, identifying genetic loci associated with the disease, including those related to lipoma formation and hormone biosynthesis.

This study identifies the cardiopharyngeal mesoderm as a non-venous source of lymphatic endothelial cells contributing to craniofacial and cardiac lymphatic networks.

The paper uses lineage tracing to show that dermal lymphatic vessels can originate from sources other than the Cdh5 lineage, highlighting the importance of temporal control in lineage tracing.

This study identifies a direct origin of lymphatic endothelial cells from non-venous angioblasts, challenging the prevailing view that they primarily derive from venous endothelium.

This study identifies that arterial mural cells provide survival and guidance cues via Cxcl12a/b and Vegfc to promote lymphatic endothelial cell migration in zebrafish.

This study shows that meningeal lymphatic networks are impaired in craniosynostosis models, leading to reduced lymphatic drainage and potential waste clearance issues in the central nervous system.

The paper identifies the role of asymmetric Pitx2 in intestinal lacteal development and shows its protective effect against fatty liver disease through lymphatic-dependent lipid transport.

This study identifies distinct roles for Notch4 and canonical Notch signaling in embryonic dermal lymphangiogenesis using mouse models.

This study shows that urgent brain vascular regeneration after ischemic stroke occurs through lymphatic transdifferentiation, mediated by EphrinB2a/EphB4a/Notch signaling in zebrafish.

The paper identifies Lyve-1/Prox-1-expressing lymphatic vessels and elements in both unaffected and affected human brains, suggesting their role in cerebral lymphatic function.

This study identifies the olfactory organ as the only brain region containing resident neutrophils and reveals its unique lymphatic vasculature and immune response to damage.

This study identifies a genetic interaction between Pkd1 and Wnt5a in controlling lymphatic vascular morphogenesis in mice, showing mutual suppression of lymphatic defects.

This study shows that lymphatic endothelial cells can transdifferentiate into blood vessel endothelial cells in zebrafish, linking cell origin to function in vascular development and regeneration.

This study shows that repeated nasal BCG exposure accelerates dural lymphatics development in neonatal mice, especially when combined with intracutaneous BCG injection.

This study shows that Vasohibin-1 mediates tubulin detyrosination in zebrafish endothelial cells, selectively regulating secondary sprouting and lymphangiogenesis in the trunk.

This study shows that tissue-resident macrophages are essential for lymphatic vessel growth and patterning during heart development by remodeling the vascular plexus.

The paper identifies a meningeal lymphatic network in zebrafish, comparable to mammals, and demonstrates its function in draining brain interstitial fluid and immune cell trafficking.

This study identifies the AIBP-CAV1-VEGFR3 axis as a regulator of lymphangiogenesis, showing that AIBP-mediated cholesterol efflux enhances VEGFC-driven lymphatic vessel formation.